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【Animal Modeling】-Establishment and evaluation of circulating liver cancer cell model in mice

【Animal Modeling】-Establishment and evaluation of circulating liver cancer cell model in mice

To establish a mouse liver cancer circulating tumor cell model using mouse liver cancer Hepa1-6 cells...

2021-10-22
[Animal Modeling]-Chemotherapeutic drug screening based on xenograft models derived from patients with pancreatic cancer

[Animal Modeling]-Chemotherapeutic drug screening based on xenograft models derived from patients with pancreatic cancer

Use the PDX model of pancreatic cancer to evaluate the therapeutic effects of clinical chemotherapy drugs and screen individualized treatment plans...

2021-10-21
【Animal modeling】-Bacterial and fungal keratitis: in vitro rabbit and human corneal models

【Animal modeling】-Bacterial and fungal keratitis: in vitro rabbit and human corneal models

Place the isolated rabbit and human cornea and scleral ring in the organ culture medium, and infect the cornea with 108 strains of Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Fusarium solani...

2021-10-21
【Animal Modeling】-Neuroinflammatory response caused by brain injury in rat lacunar infarction model

【Animal Modeling】-Neuroinflammatory response caused by brain injury in rat lacunar infarction model

Sudden brain damage leads to the release of damage-related molecular patterns (DAMPs) and subsequent activation of local immune responses...

2021-10-21
【Animal Modeling】-The phenotype characteristics of lymphocytes in HBV transgenic mice and the effect of interferon alpha on it

【Animal Modeling】-The phenotype characteristics of lymphocytes in HBV transgenic mice and the effect of interferon alpha on it

To explore the lymphocyte phenotype characteristics of hepatitis B virus (HBV) transgenic mice and the effect of interferon-α on its virological indicators and immune cell phenotype...

2021-10-21
[Animal Experiment]-The zebrafish has hidden evolutionary steps from fins to limbs

[Animal Experiment]-The zebrafish has hidden evolutionary steps from fins to limbs

Scientists at Harvard University modified the zebrafish to start forming limb-like appendages by regulating a single gene...

2021-10-21
How to build a model of post-traumatic stress disorder? -【Animal Modeling】

How to build a model of post-traumatic stress disorder? -【Animal Modeling】

Post-traumatic stress disorder (PTSD) is a mental illness that has a high incidence and a major impact on the socio-economic situation after experiencing a major traumatic event...

2021-10-21
【Animal Modeling】-The effect of TRPV4 receptor on the renal damage induced by angiotensin II in mice

【Animal Modeling】-The effect of TRPV4 receptor on the renal damage induced by angiotensin II in mice

To study the role of TRPV4 receptor in angiotensin II (angiotensin II, Ang II)-induced nephropathy, this gene uses transient receptor potential vanilloid type 4 (TRPV4) gene knockout (TRPV4-/-) small mouse...

2021-10-21
[Animal Modeling]-Experimental study of TGF-β pathway regulated by miR-335-5P mediating insulin resistance and pancreatic β cell secretion in gestational diabetic mice

[Animal Modeling]-Experimental study of TGF-β pathway regulated by miR-335-5P mediating insulin resistance and pancreatic β cell secretion in gestational diabetic mice

Treatment of gestational diabetes (GDM) mice with miR-335-5P and transforming factor-β (TGF-β), miR-335-5P regulates the TGF-β pathway and promotes pancreatic secretion to clarify, participates in enhancing β cells and insulin resistance as a treatme...

2021-10-21
【Animal Modeling】-How to build a mouse model for vaccine research

【Animal Modeling】-How to build a mouse model for vaccine research

In order to develop vaccines and study the human immune response, scientists rely on a variety of animal models, including mice that can produce human antibodies through genetically engineered B cell receptors, which are specialized antibodies that b...

2021-10-21
【Animal Modeling】-How to establish a depressive rat model?

【Animal Modeling】-How to establish a depressive rat model?

Depression is a mental illness with typical symptoms such as decreased mood, delayed thinking, and decreased speech activity...

2021-10-21
Cell therapy promotes axon remyelination in a mouse model

Cell therapy promotes axon remyelination in a mouse model

Demyelinating diseases, such as multiple sclerosis and leukocyte dystrophy, are characterized by the destruction of the protective myelin sheath surrounding neuronal axons. This demyelination may be due to an autoimmune response or impaired productio...

2021-10-21
【Animal Modeling】-Miniature Pig Mandible Defect Model

【Animal Modeling】-Miniature Pig Mandible Defect Model

10 Chinese experimental miniature pigs aged 18 months, female. Miniature pigs are under conventional anesthesia, and the premolars and first molars of the right mandible are extracted. Two months later, the animals are randomly divided into segmental...

2021-10-21
【Animal Modeling】-How to establish a heart failure model of fruit flies induced by a high-fat diet?

【Animal Modeling】-How to establish a heart failure model of fruit flies induced by a high-fat diet?

To establish a heart failure model of fruit flies induced by a high-fat diet?...

2021-10-21
【Animal Modeling】-8 gene induces reprogramming of mature blood cells in mice into hematopoietic stem cells

【Animal Modeling】-8 gene induces reprogramming of mature blood cells in mice into hematopoietic stem cells

Researchers at Boston Children\\\\\\\'s Hospital have used a mixture of transcription factors composed of eight gene switches to reprogram mature mouse blood cells into hematopoietic stem cells (HSC)...

2021-10-21
[Animal Modeling]-Potential leads to osteoporosis in male mice

[Animal Modeling]-Potential leads to osteoporosis in male mice

To observe the therapeutic effect of bakuchiol on ovariectomized male mice with osteoporosis...

2021-10-21