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Zebrafish Model: Deciphering the Cellular State and Plasticity of Melanoma

Zebrafish Model: Deciphering the Cellular State and Plasticity of Melanoma

  Dynamic cell heterogeneity is the cause of melanoma progression and treatment resistance. Advances in single-cell technology have revealed more and more tumor and microenvironmental cell states in melanoma, but little is known about their function ...

2021-02-21
Breakthrough gene therapy can treat deadly heart disease

Breakthrough gene therapy can treat deadly heart disease

A study funded by the British Heart Foundation (BHF) showed that newly discovered genetic defects in heart disease patients can be passed on to family members, thereby changing the diagnosis and treatment of the disease...

2021-02-21
The effect of overexpression of bone morphogenetic protein 4 on the proliferation and chondrogenesis of rabbit bone marrow mesenchymal stem cells

The effect of overexpression of bone morphogenetic protein 4 on the proliferation and chondrogenesis of rabbit bone marrow mesenchymal stem cells

To study the effect of adenovirus (Ad) vector infection and bone morphogenetic protein 4BMP-4 overexpression on the proliferation and cartilage formation of rabbit bone marrow mesenchymal stem cells (BMSC) in vitro...

2021-02-21
Deciphering the fine structure of coronavirus s protein provides new ideas for vaccines

Deciphering the fine structure of coronavirus s protein provides new ideas for vaccines

Recently, a team composed of Professor Peng Guiqing from the State Key Laboratory of Agricultural Microbiology of Huazhong Agricultural University and Shanghai University of Science and Technology analyzed the atomic degradation structure of the surf...

2021-02-21
[Animal modeling] -O-N-acetylglucosamine glycosylation level positively regulates the expression of angiopoietin-2 to promote tumor angiogenesis in mouse liver cancer

[Animal modeling] -O-N-acetylglucosamine glycosylation level positively regulates the expression of angiopoietin-2 to promote tumor angiogenesis in mouse liver cancer

To explore the relationship between O-N-acetylglucosamine (O-GlcNAc) glycosylation level and the expression of Angiopoietin-2 (Ang-2) in the process of liver cancer...

2021-02-21
The use of organ microphysiological system to simulate new coronavirus infection and lung tissue damage has made progress

The use of organ microphysiological system to simulate new coronavirus infection and lung tissue damage has made progress

Lung damage and immune response caused by new coronavirus infection. Human research on the pathogenic mechanism of new coronavirus and rapid drug evaluation is a new strategy and new technology...

2021-02-21
【Animal Modeling】-CREPT promotes intestinal epithelial regeneration by regulating the function of mouse intestinal stem cells

【Animal Modeling】-CREPT promotes intestinal epithelial regeneration by regulating the function of mouse intestinal stem cells

Colorectal cancer is one of the cancers with the highest incidence and mortality in China, and almost all intestinal cancer cells are derived from intestinal epithelial cells...

2021-02-21
【Animal Modeling】-Discussion of phosphorylated HER2 immunohistochemical staining method based on frozen tumor tissue sections

【Animal Modeling】-Discussion of phosphorylated HER2 immunohistochemical staining method based on frozen tumor tissue sections

To explore the optimal fixation and storage conditions of frozen tissue sections in the immunohistochemical staining experiment of phosphorylated human epidermal growth factor receptor 2 (human epidermal growth factor receptor 2, HER2)...

2021-02-21
【Animal Modeling】-Distribution of Adenovirus Type 5 in C57BL/6J Mice After Different Routes of Infection

【Animal Modeling】-Distribution of Adenovirus Type 5 in C57BL/6J Mice After Different Routes of Infection

Four methods were used to detect the distribution of adenovirus type 5 (Ad5) in C57BL6J after infection...

2021-02-20
【Animal Modeling】-Biological distribution of AAV gene transfer vector in non-human primates

【Animal Modeling】-Biological distribution of AAV gene transfer vector in non-human primates

New Rochelle, NY, January 15, 2021-A new method can be used to measure the biodistribution of adeno-associated virus gene transfer vectors in non-human primates...

2021-02-20
[Animal Modeling]-Nanotechnology can prevent premature birth in mouse research

[Animal Modeling]-Nanotechnology can prevent premature birth in mouse research

  Researchers at the Johns Hopkins University School of Medicine said in their studies on mouse and human cells that they have developed a small but effective way to prevent premature birth...

2021-02-20
【Animal Modeling】-The effect of low molecular weight heparin on the endometrial receptivity of mice with blastocyst implantation disorder through EGFR/PI3K/Akt signaling pathway

【Animal Modeling】-The effect of low molecular weight heparin on the endometrial receptivity of mice with blastocyst implantation disorder through EGFR/PI3K/Akt signaling pathway

Apply low molecular weight heparin to treat mouse blastocyst implantation dysfunction, observe the changes of EGFR/PI3K/Akt signaling pathway, and explore its mechanism of endometrial receptivity...

2021-02-19
【Animal Modeling】-Glioblastoma nanomedicine penetrates into mouse brain to eradicate recurrent brain cancer

【Animal Modeling】-Glioblastoma nanomedicine penetrates into mouse brain to eradicate recurrent brain cancer

A new study from the University of Michigan shows that a new synthetic protein nanoparticle can slide across the almost impermeable blood-brain barrier in mice, and can deliver cancer-killing drugs directly to malignant brain tumors...

2021-02-19
[Animal Modeling]-Effect of Astragalus Polysaccharides on Growth Performance, Blood Physiological and Biochemical Indexes and Incidence of Diarrhea in Reproductive Macaques

[Animal Modeling]-Effect of Astragalus Polysaccharides on Growth Performance, Blood Physiological and Biochemical Indexes and Incidence of Diarrhea in Reproductive Macaques

To study the application of diarrhea polysaccharides in the feeding and management of experimental animals from the growth potential of diarrhea polysaccharides, blood physiology and biochemistry and the incidence of reproductive macaque diarrhea...

2021-02-19
【Animal Modeling】-The application of lactose-free milk powder with deep hydrolysis of protein in the cultivation of sterile rats

【Animal Modeling】-The application of lactose-free milk powder with deep hydrolysis of protein in the cultivation of sterile rats

When cultivating sterile rats, artificial milk given after birth is very important for cultivating sterile rats. Deeply hydrolyzed lactose-free protein milk powder is easily absorbed by infants and reduces various indigestion and allergic reactions....

2021-02-19
【Animal Modeling】-Isoliquiritin improves the inflammatory response of mice with acute kidney injury induced by cisplatin through Smad3/Arid2-IR/NF-κB axis

【Animal Modeling】-Isoliquiritin improves the inflammatory response of mice with acute kidney injury induced by cisplatin through Smad3/Arid2-IR/NF-κB axis

To study the effect of isoquinoxaline (ISO) on cisplatin-induced acute kidney injury (AKI) in mice, and explore its potential regulatory mechanism...

2021-02-19