【Animal modeling】-Effect of sugar supplementation on the activation of adenosine monophosphate-activated protein kinase in the myocardium of acute exercise rats

To investigate the effect of sugar supplementation on the activation of AMPK in exercise myocardium by measuring the changes in myocardial adenosine monophosphate-activated protein kinase activity and glycogen content after acute exercise in rats...

2022-11-05

【Animal Modeling】-Determination and Analysis of Hematology and Serum Biochemical Indexes in African Green Monkeys

To detect the hematology and serum biochemical indexes of 50 healthy African green monkeys, and to analyze the hematology and serum biochemistry of African green monkeys of different genders and age groups (young group: 1-3 years old, adult group: 4-...

2022-11-05

【Animal Modeling】-Effect of Shenzhiling Oral Liquid on Early Hippocampal Synapse and Myelin Changes in App/Ps1 Double Transgenic Mice

To observe the early neuroprotective effect of Shenzhiling oral liquid on AD mice by observing the ultrastructure of myelin sheath and synapse in the CA1 region of the hippocampus and the special staining changes of myelin sheath in 3-month-old App/P...

2022-11-05

【Animal modeling】-Effect of maca combined with exercise therapy on renal mitochondrial respiratory chain enzyme activity and renal function in diabetic rats

To observe the effect of maca combined with exercise therapy on renal mitochondrial respiratory enzyme activity and renal function in diabetic rats...

2022-11-05

【Animal modeling】-Hydroxyethyl starch 40 sodium chloride injection allergic experimental study

To evaluate the allergic safety of hydroxyethyl starch 40 sodium chloride injection...

2022-11-05

【Animal Modeling】-Comparison of Different Methods of Inducing THP-1 Cell Differentiation

To optimize different methods to stimulate the directional differentiation of THP-1 cells into M1, M2 macrophages and DC cells, and lay the foundation for the study of three in vitro cell models of M1, M2 and DC...

2022-11-04

[Animal modeling] - Establishment and evaluation of an animal model of skin pruritus in guinea pigs

To optimize the dose of histamine and 4-aminopyridine (4-AP) by central composite design response plane method, in order to establish a new model of pruritus in guinea pigs...

2022-11-04

[Animal modeling] - Establishment of a functional dyspepsia model in rats with anxiety like gastric hypersensitivity induced by a new sequential stress method

To establish an anxiety like gastric hypersensitivity rat model by using a new sequential stress method...

2022-11-04

[Animal modeling] - Methodology review of experimental animal models of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is the main cause of incidence rate and mortality worldwide...

2022-11-04

[Animal modeling] - Establishment and evaluation of rat model of endometriosis with pelvic adhesion

To explore the establishment method and evaluation index of endometriosis pelvic adhesion rat model...

2022-11-04

[Animal modeling] - Establishment of a mouse model of IgA nephropathy induced by superantigen staphylococcal enterotoxin B

To establish a mouse model of IgA nephropathy and observe the biochemical and pathological characteristics of the model...

2022-11-04

[Animal modeling] Detection of salsolinol N-methyltransferase activity in 6-hydroxydopa model rats

To establish a rat model of Parkinson\'s disease (PD) with 6-hydroxydopamine (6-OHDA) and determine the activity of salsolinol N-methyltransferase (SNMT) in peripheral blood lymphocytes of rats...

2022-11-04

[Animal modeling] - Establishment and evaluation of rabbit model of premature ovarian failure induced by cyclophosphamide

To compare the methods of establishing animal models of premature ovarian failure (POF) induced by cyclophosphamide (CPF) in rabbits under different injection methods, and to find the best way of modeling, so as to provide more suitable experimental ...

2022-11-04

[Animal modeling] - Establishment of chronic renal insufficiency model in mice induced by repeated injection of cisplatin

To establish a C57BL/6 mouse model of chronic kidney disease, explore the changes of tubule injury index and interstitial fibrosis degree with cisplatin modeling dose, and provide animal experimental basis for studying the progress from AKI to CKD...

2022-11-04

[Animal modeling] - Systematic evaluation of animal models of inflammation caused by fine atmospheric particles

To explore the pathogenic mechanism of air pollution on animals, and to establish an animal model of inflammation caused by air pollution by noninvasive tracheal instillation of PM2.5 suspension in BALB/c mice?...

2022-11-04

[Animal modeling] - Establishment of muscle atrophy model of cynomolgus monkey

To establish an animal model of muscle atrophy in cynomolgus monkeys by restricting lower limb activities, and to establish a method for model evaluation?...

2022-11-04