[Animal modeling] - Effect of astragalus saponin Ⅱ on IL-21/STAT3 pathway and airway inflammation in asthmatic young rats

To investigate the effects of astragalus saponin Ⅱ on interleukin-21 (IL-21)/signal transducer and activator of transcription 3 (STAT3) pathway and airway inflammation in asthmatic young rats...

2022-12-12

【Animal Modeling】-Expression of NF-κB in Hepatocytes of Rats with Welfare Injury Induced by Braking

To study the expression changes of NF-κB in hepatocytes of rats with welfare injury induced by immobilization...

2022-12-12

【Animal Modeling】-Effects of hesperidin on antioxidant activity and gene expression of antioxidant enzymes in mice

To discuss the effect of hesperidin (HDN) on the antioxidant effect of the body...

2022-12-12

【Animal modeling】-Effect of metformin and aerobic exercise on vascular oxidative stress in type 2 diabetic rats

To evaluate the effects of metformin, aerobic exercise and the combined intervention of metformin and aerobic exercise on vascular oxidative stress in type 2 diabetic rats...

2022-12-12

[Animal modeling] Effect of single and multiple administration of Wuji Pill on pharmacokinetics in rats with irritable bowel syndrome

To determine the blood concentration of 10 active ingredients in Wuji pills at different time points after single and multiple oral administration, and compare their pharmacokinetic characteristics in normal rats and chronic visceral hypersensitive i...

2022-12-09

[Animal modeling] - Study on the effect of Tongxinluo on the early pathological changes of calcified aortic valvular disease in mice

To observe whether Tongxinluo intervention can delay the progression of calcified aortic valvular disease in the early stage...

2022-12-09

[Animal modeling] - Effect of Epimedium tribulus complex on sexual function and sperm vitality in rats

To study the effects of Epimedium Tribulus complex on sexual function and sperm motility in rats...

2022-12-09

[Animal modeling] - Neuroprotective effect and mechanism of Dendrobium nobile on MPTP induced PD mice

to investigate the neuroprotective effect of dendrobium nobile extract on parkinson\'s disease model induced by 1-methylv-4-phenyl-1,2,3,6-tetrahydropyridine in mice...

2022-12-09

[Animal modeling] - Comparative study on pharmacokinetics of Eucommia ulmoides extract in normal rats and SHR models after repeated administration

To study the pharmacokinetic differences of 7 active components of eucommia ulmoides extract after repeated administration in normal rats and spontaneously hypertensive rats, namely, pinoresinol diglucoside, geniposide, chlorogenic acid, protocatechu...

2022-12-09

[Animal modeling] - The improvement effect of Baixiangdan capsule on premenstrual anxiety caused by ovariectomy in rats

To compare the intervention effects of Baixiangdan capsule (BXD), 5-HT3R specific agonist and its antagonist, and cannabinoid receptor 1 (CB1R) specific agonist and its antagonist on premenstrual dysphoria and anxiety rats through a series of behavio...

2022-12-09

[Animal modeling] - Observation on the anesthetic effect of different doses of Zoletil combined with Serazine hydrochloride on C57BL/6J mice

C57BL/6J mice were anesthetized with different doses of Zoletil combined with Cyperazine hydrochloride to observe the anesthesia related time of mice under different anesthetic doses, so as to provide reference for various mouse operations and relate...

2022-12-08

[Animal modeling] - Based on 16S rRNA sequencing, analyze the effects of two reoviruses on intestinal flora of mice

To investigate the effects of T1L and NBV reovirus on intestinal flora in mice...

2022-12-08

[Animal modeling]- Effect of low expression of lipoic acid synthase on antioxidant capacity of mice

To establish a genetically modified mouse with low expression of lipoic acid synthase gene and detect its antioxidant capacity...

2022-12-08

[Animal modeling] - Trifolium tea herb mediation I κ B- α Effect of phosphorylation on liver fibrosis induced by CCl4 in rats

To explore the effect of Camellia trifoliata L κ B- α And its phosphorylation down regulates the signal pathway of nuclear transcription factor to alleviate carbon tetrachloride induced liver fibrosis in rats...

2022-12-08

[Animal modeling] Effect of low expression of lipoic acid synthase on antioxidant capacity of mice

To establish a genetically modified mouse with low expression of lipoic acid synthase gene and detect its antioxidant capacity...

2022-12-08

[Animal modeling] - Based on 16S rRNA sequencing, analyze the effects of two reoviruses on intestinal flora of mice

To investigate the effects of T1L and NBV reovirus on intestinal flora in mice...

2022-12-08