[Animal modeling] - Construction and identification of a humanized mouse model immunized with prostate cancer

To construct a humanized mouse model of immune system and transplant it into a human prostate cancer cell line for the study of immunotherapeutic drugs for prostate cancer...

2022-12-15

[Animal modeling] - Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

To explore the effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia (FD)...

2022-12-14

[Animal modeling] - Study on the improvement effect and mechanism of paeoniflorin on Bayk8644 induced depression and anxiety like behavior in rats

To explore the pharmacological mechanism of paeoniflorin in improving depression and anxiety like behavior in rats based on L-type voltage dependent calcium channel...

2022-12-14

[Animal modeling] - Leptin receptor knockout causes microglia activation in rat brain tissue

To study the morphological and functional changes of microglia in rat brain after leptin receptor (LEPR) gene knockout, and explore the function of leptin receptor in microglia...

2022-12-14

[Animal modeling] - Changes of C-reactive protein and inflammatory factors in the high altitude multiple organ dysfunction syndrome model of the Fenma pig

To study the tumor necrosis factor (TNF) in the high altitude multi organ dysfunction syndrome (MODS) model of pteridophyte pigs- α Interleukin-1 β And the change characteristics of C-reactive protein in the process of inflammatory reaction...

2022-12-14

[Animal modeling] - Preliminary study on the effect of lipopolysaccharide on lung tissue of naked mole rats

To observe and analyze the effects of lipopolysaccharide (LPS) on the morphological structure and pathological indexes of lung tissue in nude mole rats, and to explore whether there is LPS tolerance in nude mole rats...

2022-12-14

[Animal modeling] - Effect of Spirillum hepaticum infection on chronic colitis model induced by dextran sodium sulfate in mice

To investigate the effect of Spirillum hepaticum infection on chronic colitis induced by dextran sodium sulfate in mice...

2022-12-14

[Animal modeling]- α- Effect of Roxnipin on Immune Function in Immunosuppressive Mice

discussion α- The effect of Roxniphyllin on the immune function of the immunosuppressive model of mice induced by cyclophosphamide provides an experimental basis for the follow-up mechanism research and the development of new drugs to increase immune...

2022-12-14

[Animal modeling] - The therapeutic effect of rapamycin on primary sclerosing cholangitis induced by DDC in mice

To investigate the therapeutic effect of rapamycin on primary sclerosing cholangitis (PSC) induced by 3,5-diethylcarbonyl 1,4-dihydrochloride in mice and its potential mechanism...

2022-12-14

[Animal modeling] - Acupuncture can improve the symptoms of insomnia rats and affect their spontaneous activities by regulating GABA Gln metabolism

To study the effect of acupuncture on the improvement of symptoms and spontaneous activities in insomnia rats, and explore its possible mechanism...

2022-12-13

[Animal modeling] - Inhibitory effect of cytomegalovirus on some immune indexes of mice implanted with polymethylmethacrylate

To study the inhibitory effect of cytomegalovirus (CMV) on immune response of mice implanted with polymethyl methacrylate (PMMA)...

2022-12-13

[Animal modeling] - Protective effect of curcumin on acute renal injury in rats with pregnancy induced hypertension

To investigate the protective effect of curcumin on acute renal injury induced by pregnancy induced hypertension in rats and explore its potential mechanism...

2022-12-13

[Animal modeling] - Experimental study on lung tissue damage in rats caused by dental grinding dust

To evaluate the effects of cobalt chromium molybdenum metal , zirconia porcelain and polymethyl methacrylate resin on lung injury in rats...

2022-12-13

[Animal modeling] - Effect of metformin regulating miR-34a on airway inflammation in COPD rats

To investigate the effects of metformin (Met) on airway inflammation in rats with chronic obstructive pulmonary disease (COPD)...

2022-12-13

[Animal modeling] Study on the improvement of renal function of type 1 diabetes mice by vEGF-A inhibitor sFLT-1

To investigate whether sFLT-1, a VEGF-A inhibitor, can reverse renal function damage in type 1 diabetes mice by inhibiting the activation of vascular endothelial cells and inflammatory response...

2022-12-13

[Animal modeling] - Relevant changes of rat uterine ligament fibroblasts induced by hydrogen peroxide in vitro

To investigate the effects of oxidative stress on the proliferation, apoptosis, collagen synthesis and the expression of inflammatory factors of uterine ligament fibroblasts...

2022-12-13