【Animal Modeling】-Tumor necrosis factor-α-induced protein-8-like molecule 2 promotes apoptosis of CD4-positive T cells in heat-injured mice

To investigate the effect of tumor necrosis factor-α-induced protein-8-like molecule 2 (TIPE2) on apoptosis of spleen CD4+ T lymphocytes in a mouse model of severe scald....

2022-09-23

【Animal modeling】-FGF-2/PELA/BMP-2 microcapsule scaffold promotes the osteogenic differentiation of rat periosteum-derived stem cells

To observe the effect of fibroblast growth factor-2/polylactic acid-polyethylene glycol-polylactic acid/bone morphogenetic protein-2 (FGF-2/PELA/BMP-2) microcapsule scaffold on the formation of periosteum-derived stem cells in SD rats. Bone different...

2022-09-23

【Animal modeling】-Mechanism of recombinant adenovirus-mediated adiponectin gene on atherosclerosis in ApoE-/- mice

To study the inhibitory effect of adenovirus-mediated adiponectin (APN) overexpression on atherosclerosis (AS) in ApoE-/- mice and its effect on NF-κB signaling pathway...

2022-09-23

【Animal Modeling】-Effect of Shenzhiling Oral Liquid on Early Hippocampal Synapse and Myelin Changes in App/Ps1 Double Transgenic Mice

To observe the early neuroprotective effect of Shenzhiling oral liquid on AD mice by observing the ultrastructure of myelin sheath and synapse in the CA1 region of the hippocampus and the special staining changes of myelin sheath in 3-month-old App/P...

2022-09-23

【Animal modeling】-Effect of metformin on cognitive dysfunction and PI3K/Akt pathway in Alzheimer

To investigate the effect of metformin on phosphatidylinositol-3-kinase/protein kinase B pathway and cognitive dysfunction in Alzheimer\\\'s disease rats...

2022-09-23

【Animal Modeling】-Comparison of three methods of tracheal infusion of bleomycin to induce pulmonary fibrosis in mice

To inject bleomycin into C57BL/6J mice to induce pulmonary fibrosis by three different methods: lumbar puncture tracheal intubation, indwelling needle tracheal intubation and tracheotomy, and to explore the modeling of lumbar puncture tracheal intuba...

2022-09-23

【Animal Modeling】-Effect of Maiqi Jiangtang Pill on blood sugar in ob/ob mice

To study the effect of Maiqi Jiangtang Pills on blood sugar in ob/ob mice...

2022-09-23

【Animal modeling】-Effects of bile duct ligation and recanalization on the phenotype and NOX4 protein expression in rat liver

To design and establish a rat liver fibrosis model with bile duct ligation and recanalization, and to observe the effects of bile duct ligation and recanalization on epithelial-mesenchymal phenotype and oxidative stress-related protein expression in...

2022-09-23

【Animal Model】-Experimental stress-induced impairment of mouse welfare and the effect of music intervention

To explore the degree of damage to animal welfare caused by routine experimental operations and the effect of music intervention...

2022-09-23

【Animal Modeling】-Research on the analgesic effects of Lugai Qishan Fluoxane on labor and delivery based on MAPK signaling hypoxia

To investigate the effect of sevoflurane labor analgesia on hypoxia in neonatal rats based on the mitogen-activated protein kinase signaling pathway...

2022-09-23

【Animal modeling】-Protective effect of trigonelline on testicular injury induced by heat stress in mice

To study the protective effect of trigonelline on heat stress-induced testicular injury in mice...

2022-09-23

【Animal modeling】-Characteristics of liver pathological damage in db/db mice with spontaneous type 2 diabetes

To dynamically observe the pathological changes and characteristics of the liver of db/db mice with spontaneous type 2 diabetes mellitus, and to provide the basic theory and experimental basis for the experimental study of using the liver of db/db mi...

2022-09-22

【Animal Modeling】-Minocycline inhibits the hyperpolarization-activated current of glial neurons in the dorsal horn of rat spinal cord

To study the effect of minocycline on the hyperpolarization-activated current (Ih) of colloidal (SG) neurons in the spinal dorsal horn of rats...

2022-09-22

【Animal modeling】-The effect of long-term consumption of Polygonum multiflorum on the hematopoietic system of mice

To investigate the changes of mouse hematopoietic system after long-term consumption of Polygonum multiflorum...

2022-09-22

【Animal modeling】-Effect of deoxycholic acid on the growth of ileal organoids in C57BL/6 mice

To establish a mouse intestinal organoid culture system, and to investigate the effect of deoxycholic acid (DCA) on the growth of intestinal organoids...

2022-09-22

【Animal modeling】-The acute toxicity of CKLF1-C19 to Kunming mice

To study the acute toxicity of the polypeptide CKLF1-C19 of chemokine-like factor 1 (CKLF1) on Kunming mice...

2022-09-22