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【Animal Modeling】-Construction of Raf-1 Gene Recombinant Adenovirus siRNA Vector and Its Effect on Rat Cardiomyocyte Hypertrophy

【Animal Modeling】-Construction of Raf-1 Gene Recombinant Adenovirus siRNA Vector and Its Effect on Rat Cardiomyocyte Hypertrophy

To construct a recombinant adenovirus vector that specifically inhibits the Raf-1 gene in rats, and transduce it into rat cardiomyocytes in vitro for functional validation...

2022-03-25
How to prepare a rat model of Parkinson\\\\

How to prepare a rat model of Parkinson

Modeling materials Animal: SD rat, male, body weight (200±10) g; drug: manganese chloride reagent...

2022-03-25
【Animal modeling】-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

【Animal modeling】-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

To discuss the maintenance effect of Apelin-13 on focal cerebral ischemia-reperfusion injury (CIRI) in rats and its possible mechanism...

2022-03-25
【Animal Modeling】-Effect of Jin Siwei on the brain cholinergic system of scopolamine-induced memory impairment mice

【Animal Modeling】-Effect of Jin Siwei on the brain cholinergic system of scopolamine-induced memory impairment mice

To establish a scopolamine memory impairment model, use the traditional Chinese medicine compound Jinsi to intervene, observe the effect of Jinsi on the behavior and cholinergic system of the scopolamine-induced memory impairment model in mice, and e...

2022-03-25
【Animal modeling】-Effect of maca combined with exercise therapy on renal mitochondrial respiratory chain enzyme activity and renal function in diabetic rats

【Animal modeling】-Effect of maca combined with exercise therapy on renal mitochondrial respiratory chain enzyme activity and renal function in diabetic rats

To observe the effect of maca combined with exercise therapy on renal mitochondrial respiratory enzyme activity and renal function in diabetic rats...

2022-03-25
【Animal modeling】-M4 receptor blocker MT3 inhibits form deprivation myopia in guinea pigs

【Animal modeling】-M4 receptor blocker MT3 inhibits form deprivation myopia in guinea pigs

To investigate the inhibitory effect of the highly selective M4 receptor blocker MT3 on form deprivation myopia in guinea pigs and its potential mechanism...

2022-03-25
【Animal modeling】-Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

【Animal modeling】-Effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

To explore the effect and mechanism of Shenqu Xiaoshi Oral Liquid on gastrointestinal motility in functional dyspepsia (FD) mice...

2022-03-25
【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

To study the effects of experimental intervention of normal saline on the microflora and content of short-chain fatty acids in the caecum of broilers, in order to provide a theoretical basis for the study of early microbiota intervention experiments...

2022-03-25
【Animal Modeling】-Effects of ethinylestradiol exposure before pregnancy on changes in glucose metabolism and the expression of genes related to hepatic glucose metabolism in offspring of rats

【Animal Modeling】-Effects of ethinylestradiol exposure before pregnancy on changes in glucose metabolism and the expression of genes related to hepatic glucose metabolism in offspring of rats

To use SD rats as a model to observe the effects of pre-pregnancy ethinyl estradiol exposure on the changes of glucose metabolism in offspring and the expression of genes related to glucose metabolism in the liver...

2022-03-25
【Animal Modeling】-Glucagon-like polypeptide-1 improves learning and memory ability in type 2 diabetic rats

【Animal Modeling】-Glucagon-like polypeptide-1 improves learning and memory ability in type 2 diabetic rats

To observe the improvement effect of diabetes treatment drug glucagon-like peptide-1 (GLP-1) on learning and memory dysfunction in diabetic rats...

2022-03-25
【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

To investigate the effect of curcumin on glucose transport and phosphatidylinositol kinase-3 (PI3K)/protein kinase B (Akt) signaling pathway in adipocytes of type 2 diabetes mellitus (T2DM) rats...

2022-03-25
【Animal modeling】-Experimental observation of porcine circovirus type 3 infection in BALB/c mice

【Animal modeling】-Experimental observation of porcine circovirus type 3 infection in BALB/c mice

To study the infection of porcine circovirus type 3 in BALB/c mice...

2022-03-25
【Animal modeling】-Study on the protective effect of salvianolic acid A on the kidney of ZDF rats and the inhibition of lipoprotein-associated phospholipase A2

【Animal modeling】-Study on the protective effect of salvianolic acid A on the kidney of ZDF rats and the inhibition of lipoprotein-associated phospholipase A2

To observe the protective effect of salvianolic acid A on nephropathy in Zucker diabetic obese rats and its effect on the expression of lipoprotein-related phospholipase A2...

2022-03-25
【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

To study the effect of Astragalus on endoplasmic reticulum stress response (ERS) in vascular remodeling in hypertensive rats, and to explore the molecular mechanism of its vascular protection...

2022-03-25
【Animal modeling】-Distribution and differential expression of Hba-α protein in hatched blastocysts and dormant embryos of mice before and after programmed freezing

【Animal modeling】-Distribution and differential expression of Hba-α protein in hatched blastocysts and dormant embryos of mice before and after programmed freezing

To explore the distribution and differential expression of Hba-α protein in hatched blastocysts and dormant embryos of mice before and after freezing by means of programmed freezing, so as to provide a theoretical basis for the future development and...

2022-03-25
【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

【Animal Modeling】-Preliminary study on the effect of lipopolysaccharide on the lung tissue of naked mole rats

To observe and analyze the effect of lipopolysaccharide on the morphological structure and pathological indexes of naked mole rat lung, and to preliminarily explore whether naked mole rat has LPS tolerance...

2022-03-25