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Comparative study of bleomycin and endotoxin-induced pulmonary fibrosis in two strains of mice

Comparative study of bleomycin and endotoxin-induced pulmonary fibrosis in two strains of mice

By comparing the degree of pulmonary fibrosis induced by bleomycin and endotoxin in ICR and C57BL/6 strains of mice, a suitable mouse pulmonary fibrosis model can be established...

2020-10-22
Preparation and evaluation of MPTP-induced C57BL/6 mouse Parkinson model

Preparation and evaluation of MPTP-induced C57BL/6 mouse Parkinson model

Establish a stable 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson\'s model in C57BL/6 mice, and conduct behavioral evaluation of the model...

2020-10-22
Application of mouse models in translational medicine research

Application of mouse models in translational medicine research

The mouse model has become an irreplaceable model animal for biomedical research such as studying gene functions and pathogenic mechanisms, establishing human-related disease models, and evaluating the safety and effectiveness of research and develop...

2020-10-22
Miniature pig obesity model induced by high sugar and high fat diet

Miniature pig obesity model induced by high sugar and high fat diet

To explore the effects of high-fat and high-sugar feed on fat distribution and blood biochemical indexes of Bama mini-pigs...

2020-10-22
Application analysis of melasma animal model based on data mining

Application analysis of melasma animal model based on data mining

Analyze the current status of the application of chloasma animal models, and lay a good foundation for animal experiments in order to explore the theoretical knowledge of chloasma, explore new therapies, and develop new drugs, and improve the scienti...

2020-10-22
Comparative Study on Different Methods of Making Visceral Hypersensitivity Model of Irritable Bowel Syndrome

Comparative Study on Different Methods of Making Visceral Hypersensitivity Model of Irritable Bowel Syndrome

Study different methods to make IBS visceral hypersensitivity pup models, and evaluate their visceral sensitivity and stability...

2020-10-22
Rabbit model: Tissue engineering periosteum to repair irregular bone defects

Rabbit model: Tissue engineering periosteum to repair irregular bone defects

In previous studies, long bone defects were successfully repaired by tissue-engineered periosteum (TEP), which is formed by combining rabbit bone marrow mesenchymal stem cells with the submucosa of the small intestine. This study explores the feasibi...

2020-10-22
Isoliquiritin improves inflammation in mice with acute kidney injury induced by cisplatin through Smad3/Arid2-IR/NF-κB axis

Isoliquiritin improves inflammation in mice with acute kidney injury induced by cisplatin through Smad3/Arid2-IR/NF-κB axis

To study the effect of isoliquiritin (ISO) on cisplatin-induced acute kidney injury (AKI) mice and explore the underlying regulatory mechanism...

2020-10-22
What is the molecular mechanism of hypoxia-inducible factor hif-3α enhancing fish hypoxia tolerance?

What is the molecular mechanism of hypoxia-inducible factor hif-3α enhancing fish hypoxia tolerance?

Hypoxia-inducible factors HIF-1α and HIF-2α are the key regulators of hypoxia stress in cells. So far, the research on their functions has been relatively clear...

2020-10-22
Not sensitive to fishy smell? Maybe this gene has been mutated

Not sensitive to fishy smell? Maybe this gene has been mutated

It is the same fish, some people think it is very fresh, some people think it is very fishy, why is this? A new genome-wide association study shows that people\'s sensitivity to fishy smell may be affected by mutations in the olfactory receptor genes...

2020-10-22
What does carp genome doubling promote the phenotypic diversity of the blood oxygen system?

What does carp genome doubling promote the phenotypic diversity of the blood oxygen system?

The diversification of the blood oxygen system not only reflects the physiological diversity of species, but also reflects the adaptability of species to the environment from the side...

2020-10-22
The latest research progress of zebrafish heart regeneration

The latest research progress of zebrafish heart regeneration

Human myocardial infarction will lead to ventricular remodeling and eventually heart failure, which is one of the main causes of death worldwide...

2020-10-22
Discovered that conserved regenerative responsive enhancers actually affect vertebrate regeneration

Discovered that conserved regenerative responsive enhancers actually affect vertebrate regeneration

In a new study, researchers from the Stovalls Medical Institute, the Howard Hughes Medical Institute, and Stanford University found that the conservative regenerative responsive enhancer (regeneration) associated with tail regeneration in two fish sp...

2020-10-22
Stable expression of human coagulation factor IX gene in mouse adipose stem cells

Stable expression of human coagulation factor IX gene in mouse adipose stem cells

Transfect the recombinant adenovirus carrying the human coagulation factor IX (hFIX) gene (F9) into C57BL/6 mouse adipose-derived stem cells (ADSC), after subculture, observe whether F9 is in the ADSC Stable expression to explore whether ADSC can be ...

2020-10-22
Sh2b1 knockout mice-the key mechanism of leptin to promote weight loss

Sh2b1 knockout mice-the key mechanism of leptin to promote weight loss

Leptin is a protein hormone secreted by adipose tissue, which can stimulate the sympathetic nervous system (SNS), promote energy expenditure and reduce weight, but the underlying molecular mechanism is still unclear...

2020-10-22
Comparative analysis of genetic detection of BALB/c mice by microsatellite and biochemical locus methods

Comparative analysis of genetic detection of BALB/c mice by microsatellite and biochemical locus methods

Use microsatellite DNA markers to test the genetic quality of BALB/c mice, and compare with the current national standard biochemical marker methods, explore its application in genetic monitoring of inbred mice, and lay the foundation for the establi...

2020-10-22