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【Animal Modeling】-Comparison of the biological characteristics of the eyeball of two guinea pig strains and research on the mechanism of retinal myopia

【Animal Modeling】-Comparison of the biological characteristics of the eyeball of two guinea pig strains and research on the mechanism of retinal myopia

To compare the biological characteristics of the eyeballs of Zmu-1:DHP and DHP guinea pigs, and to preliminarily explore the retina-related mechanism of spontaneous myopia in Zmu-1:DHP guinea pigs...

2022-04-25
[Animal modeling]-Diphtheria toxin-induced myocarditis in mice

[Animal modeling]-Diphtheria toxin-induced myocarditis in mice

Reproduction method For experimental mice weighing 25 to 30 g, first observe the experimental animals for 3 days, select healthy animals as models, and then pass the diphtheria toxin stock solution of 7.30 μg/g body weight through the tail of the mou...

2022-04-25
【Animal modeling】-PCR detection and analysis of various bacteria in experimental rats and mice

【Animal modeling】-PCR detection and analysis of various bacteria in experimental rats and mice

Investigate the bacteria carrying status of rats and mice in Shanghai laboratory animal production facilities...

2022-04-25
【Animal modeling】-C57BL/6J mouse frozen-thawed IVF prokaryotic embryos used for Cas9 microinjection

【Animal modeling】-C57BL/6J mouse frozen-thawed IVF prokaryotic embryos used for Cas9 microinjection

To explore the feasibility of using Cas9 injection in mice after in vitro fertilization freeze-thaw...

2022-04-25
【Animal Modeling】-Guinea Pig Pulmonary Tuberculosis Model

【Animal Modeling】-Guinea Pig Pulmonary Tuberculosis Model

The reproduction method uses female Hartley guinea pigs. In the middle of the logarithmic growth phase, dilute Mycobacterium tuberculosis with sterile redistilled water to the required inoculation concentration, and add 5 ml of distilled water contai...

2022-04-25
【Animal Modeling】-A Modified Rat Jugular Vein Intubation for Autonomous Drug Administration and Its Application

【Animal Modeling】-A Modified Rat Jugular Vein Intubation for Autonomous Drug Administration and Its Application

To introduce an improved rat jugular vein cannula fabrication method and jugular vein cannulation operation method, and apply it to an experimental study of autonomous drug administration in rats to evaluate the service life and application effect of...

2022-04-25
【Animal modeling】-Topical application of dexamethasone to reduce intraocular pressure and body weight of rats

【Animal modeling】-Topical application of dexamethasone to reduce intraocular pressure and body weight of rats

Glaucoma is a common cause of visual impairment, affecting approximately 70 million people worldwide. This condition is characterized by the selective loss of retinal ganglion cells (RGCs) and their nerve fibers, resulting in a gradual narrowing of t...

2022-04-25
【Animal modeling】-Study on the protective effect of curcumin on cognitive function and neurological function in mice with cerebral ischemia-reperfusion injury

【Animal modeling】-Study on the protective effect of curcumin on cognitive function and neurological function in mice with cerebral ischemia-reperfusion injury

To investigate the effect of curcumin on cognitive function, neurological function and mechanism of cerebral ischemia-reperfusion injury in mice...

2022-04-25
【Animal modeling】-Establishment and identification of vitamin D receptor gene knockout mouse strain

【Animal modeling】-Establishment and identification of vitamin D receptor gene knockout mouse strain

To explore the optimal breeding method and identification method of vitamin D receptor (VDR) knockout mice, and to provide animal models for further study of VDR function and related diseases...

2022-04-25
【Animal Modeling】-Effect and mechanism of androgens on gastric mucosal mitochondrial function in aged rats

【Animal Modeling】-Effect and mechanism of androgens on gastric mucosal mitochondrial function in aged rats

To investigate the effect and mechanism of androgens on gastric mucosal mitochondrial function in aged rats with orchiectomy (GDX)...

2022-04-25
【Animal modeling】-Analysis of microenvironment simulation of SPF experimental rabbit rearing under dynamic conditions

【Animal modeling】-Analysis of microenvironment simulation of SPF experimental rabbit rearing under dynamic conditions

In this study, a comparative analysis of the parameters of the macro environment and the rearing microenvironment under the dynamic conditions of the SPF laboratory animal room was carried out, in order to explore the influence of the rearing microen...

2022-04-25
【Animal Modeling】-Intervention and Mechanism of Low Molecular Weight Heparin Calcium on Mouse Embryonic Implantation

【Animal Modeling】-Intervention and Mechanism of Low Molecular Weight Heparin Calcium on Mouse Embryonic Implantation

To investigate the intervention effect and mechanism of low molecular weight heparin calcium on mouse embryo implantation...

2022-04-25
【Animal Modeling】-Efficacy and safety of electroacupuncture combined with methylprednisolone on intervertebral disc prolapse in rats

【Animal Modeling】-Efficacy and safety of electroacupuncture combined with methylprednisolone on intervertebral disc prolapse in rats

To observe the effects of electroacupuncture combined with methylprednisolone and electroacupuncture or methylprednisolone alone on limb motor function and nerve cell Nissl bodies in rat models 24 hours after intervertebral disc prolapse, to provide...

2022-04-25
[Animal model]-Genetically modified rheumatoid arthritis (RA)

[Animal model]-Genetically modified rheumatoid arthritis (RA)

Human tumor necrosis factor transgenic mouse model [Modeling mechanism] Tumor necrosis factor-α (TNF-α) is mainly secreted by activated macrophages, activated T cells, NK cells and mast cells. It also secretes a small amount...

2022-04-25
【Animal Modeling】- Breeding and Genotyping of Type I Interferon Receptor (Ifnar) Knockout Mice

【Animal Modeling】- Breeding and Genotyping of Type I Interferon Receptor (Ifnar) Knockout Mice

To analyze the breeding and identification of Ifnar knockout mice, and to provide an ideal animal model for the study of various viruses...

2022-04-25
【Animal Modeling】-The role of cAMP/CREB/BDNF signaling pathway in vortioxetine against depression-like behavior in mice

【Animal Modeling】-The role of cAMP/CREB/BDNF signaling pathway in vortioxetine against depression-like behavior in mice

To study the effect of vortioxetine, a novel antidepressant, on cyclic adenosine monophosphate/cyclic adenosine monophosphate response element binding protein/brain-derived neurotrophic factor (cAMP/CREB/BDNF) signal transduction pathway...

2022-04-25
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