[Animal modeling] - Preliminary study on myocardial injury model of rhesus monkey induced by isoproterenol

To establish a model of myocardial injury induced by isoproterenol in rhesus monkeys...

2022-10-20

[Animal modeling] - Establishment and comparison of in situ model of pancreatic cancer in mice suitable for minimally invasive ablation therapy

To explore the advantages and disadvantages of establishing an in situ model of pancreatic cancer in mice by tumor cell injection and tumor tissue transplantation, and to provide a technical reference for establishing an in situ model of pancreatic c...

2022-10-20

[Animal modeling] - Construction and evaluation of a mouse model of chronic cardiac toxicity induced by doxorubicin

To evaluate the effects of doxorubicin in different concentrations on cardiac toxicity in mice based on pathological changes...

2022-10-20

[Animal modeling] Establishment and evaluation of an animal model of Alzheimer's disease combined with phlegm and blood stasis

To explore and establish a reliable animal model of Alzheimer\'s disease combined with phlegm and blood stasis syndrome, and to provide the corresponding animal model for the prevention and treatment of AD by traditional Chinese medicine and provide ...

2022-10-20

[Animal modeling] - Establishment of endothelial conditional knockout EMCN mouse model and comparative analysis of lung metastasis of tumor

To establish a mouse model of endothelial cell conditional knockout EMCN gene, and investigate the difference of lung metastasis between C57BL/6 mice and endothelial cell conditional knockout EMCN mice...

2022-10-20

[Animal modeling] - Primary cell brain metastasis model of small cell lung cancer

This study intends to isolate and culture primary small cell lung cancer cells that retain the important features and functions of the original tumor, and build a mouse model of SCLC primary cell brain metastasis on this basis, so as to provide a mor...

2022-10-20

[Animal modeling] Study on biological characteristics of tree shrew model of H1N1 influenza virus

To establish a tree shrew model infected with H1N1 influenza virus, and to investigate the dynamics of influenza virus and its distribution in respiratory tissues...

2022-10-20

[Animal modeling] - Preparation and identification of human angiotensin converting enzyme 2 (ACE2) BAC transgenic mouse model

To obtain a humanized mouse model of hACE2 containing the full length hACE2 gene sequence, and to provide an important tool for the research of cardiovascular disease, pathogenesis of COVID-19, and drug and vaccine development...

2022-10-20

[Animal modeling] Establishment of a mouse model of chronic infection with LCMV-CL13 and analysis of its BCR mutation

To establish a mouse model of chronic lymphocytic choriomeningitis virus LCMV-CL13 infection and analyze its possibility as a model for the study of high-frequency mutation of B cell receptor...

2022-10-20

【Animal Modeling】-Parasitic Infection and Drug Purification Effect of Closed Group Meridian Gerbils

To lay a foundation for the establishment of a clean-grade Meridian gerbil population, and to provide a reference for formulating the detection standard of Meridian gerbil parasites...

2022-10-20

【Animal Modeling】-Animal Model of Chronic Bronchitis

Chronic bronchitis (chronic bronchitis) refers to chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues caused by infectious or non-infectious factors. The pathological features of chronic bronchitis are bronchial...

2022-10-20

[Animal modeling] - Overexpression of LAMP2A in substantia nigra improves motor function of Parkinson's disease rhesus monkey model

To observe the effect of over expression of lysosome associated membrane protein 2A in substantia nigra on motor behavior of experimental monkeys induced by chaperone mediated autophagy in a Parkinson\'s disease rhesus monkey model...

2022-10-19

[Animal modeling] - Construction and evaluation of humanized mouse model of pancreatic cancer immune system

To construct and evaluate a humanized mouse model of pancreatic cancer immune system in order to provide an ideal preclinical model for immunotherapy of pancreatic cancer...

2022-10-19

[Animal modeling] - Establishment of diffuse cerebral thrombosis model in rats induced by arachidonic acid

To establish and optimize the model of diffuse cerebral thrombosis induced by arachidonic acid in rats...

2022-10-19

[Animal modeling] Preparation of a mouse model of diarrhea predominant irritable bowel syndrome induced by acetic acid combined with restraint stress

To establish a mouse model of diarrhea predominant irritable bowel syndrome (IBS) by rectal perfusion with 3% acetic acid combined with restraint stress, and evaluate the feasibility of the model...

2022-10-19

[Animal modeling] Comparative study on visceral hypersensitivity model induced by combined method

To observe the effect of visceral hypersensitivity model of irritable bowel syndrome established by maternal infant separation combined with mechanical stimulation and drug combined with chronic stress, and discuss the advantages and disadvantages of...

2022-10-19