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【Animal Modeling】-Animal Model of Sclerosing Glomerulonephropathy

【Animal Modeling】-Animal Model of Sclerosing Glomerulonephropathy

Sclerosing glomerulonephritis is the end stage of many types of glomerulonephritis, rather than an independent pathological type of glomerulonephritis. The pathological changes are characterized by extensive glomerulosclerosis, renal tubular atrophy...

2022-09-21
【Animal Model】-Effect of X-ray whole body irradiation on the function of hematopoietic immune system in KKAy mice with type 2 diabetes

【Animal Model】-Effect of X-ray whole body irradiation on the function of hematopoietic immune system in KKAy mice with type 2 diabetes

To observe the damage effect of X-ray whole body irradiation on the function of hematopoietic immune system in KKAy mice, a model of type 2 diabetes mellitus, and compare it with control C57 mice...

2022-09-21
【Animal Modeling】-Zucker Diabetic Obesity Rats Cerebrovascular Disease Characteristics and Pathogenesis Study

【Animal Modeling】-Zucker Diabetic Obesity Rats Cerebrovascular Disease Characteristics and Pathogenesis Study

To observe the pathological characteristics of cerebrovascular disease in Zucker diabetic obese (ZDF) rats, and to preliminarily explore its pathogenesis, so as to provide experimental basis and theoretical basis for the application of ZDF rats...

2022-09-21
【Animal Modeling】-Effect of Bushen Yangxue Recipe on Anti-Müllerian Hormone in Rats with Premature Ovarian Failure

【Animal Modeling】-Effect of Bushen Yangxue Recipe on Anti-Müllerian Hormone in Rats with Premature Ovarian Failure

To establish a rat model of premature ovarian failure induced by Tripterygium wilfordii polyglycosides, and to study the effect of Bushen Yangxue Recipe on anti-mullerian in rats with premature ovarian failure...

2022-09-21
【Animal modeling】-MMP12 deletion causes changes in macrophages in blood and white fat in mice

【Animal modeling】-MMP12 deletion causes changes in macrophages in blood and white fat in mice

MMP12, also known as macrophage elastase, can almost decompose various extracellular matrix components and vascular components, and is related to the recruitment of monocytes. It was also found that MMP12 is involved in the invasion and metastasis of...

2022-09-21
【Animal Modeling】-Isolation, Culture and Identification of Mouse Lung Mesenchymal Stem Cells

【Animal Modeling】-Isolation, Culture and Identification of Mouse Lung Mesenchymal Stem Cells

To establish a stable technique for the isolation, culture and identification of mouse lung mesenchymal stem cells, and to study the mechanism of lung tissue repair and regeneration using mouse lung mesenchymal stem cells...

2022-09-21
【Animal modeling】-The expression changes and effects of BDNF and its receptor TrkB in hypoxia-preconditioned mice

【Animal modeling】-The expression changes and effects of BDNF and its receptor TrkB in hypoxia-preconditioned mice

To explore the expression changes and effects of BDNF, TrkB receptor and BDNF/TrkB signaling pathway in acute hypoxia and hypoxia preconditioning mice, to further improve the molecular mechanism of hypoxia preconditioning neuroprotection, and to prov...

2022-09-21
【Animal Modeling】-Adenine-induced abnormal bone and mineral metabolism in a rat model of chronic kidney disease

【Animal Modeling】-Adenine-induced abnormal bone and mineral metabolism in a rat model of chronic kidney disease

To observe the biochemical markers of mineral metabolism in adenine-induced chronic kidney disease rat model? The characteristics of vascular calcification and renal bone disease?...

2022-09-20
【Animal Modeling】-Comparative study of hepatotoxicity between matrine and oxymatrine in vitro and in vivo models

【Animal Modeling】-Comparative study of hepatotoxicity between matrine and oxymatrine in vitro and in vivo models

To compare the hepatotoxicity of matrine and oxymatrine, to explore the severity and characteristics of their toxicity, and to preliminarily clarify the toxicity mechanism?...

2022-09-20
【Animal Modeling】-Discussion on the feasibility of acupuncture treatment of chronic myocardial ischemia miniature pig model series

【Animal Modeling】-Discussion on the feasibility of acupuncture treatment of chronic myocardial ischemia miniature pig model series

To investigate the feasibility of a series of methods for treating chronic myocardial ischemia in miniature pigs with an Ameroid constriction ring placed in the left anterior descending artery with embedded needles...

2022-09-20
【Animal Modeling】-Establishment of a mouse model of chronic renal insufficiency induced by repeated injection of cisplatin

【Animal Modeling】-Establishment of a mouse model of chronic renal insufficiency induced by repeated injection of cisplatin

To construct a C57BL/6 mouse model of chronic kidney disease, and to explore the changes of its tubular injury indexes and interstitial fibrosis with the dose of cisplatin, so as to provide an animal experimental basis for studying the progression fr...

2022-09-20
【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

To investigate the effect and mechanism of 17β-estradiol on the apoptosis of primary cultured cortical neurons induced by propofol...

2022-09-19
【Animal modeling】-Effect of curcumin on the expression of hepatic 11β-HSD1 and insulin resistance in rats with non-alcoholic fatty liver disease

【Animal modeling】-Effect of curcumin on the expression of hepatic 11β-HSD1 and insulin resistance in rats with non-alcoholic fatty liver disease

To observe the effect of curcumin on the expression of hepatic 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and insulin resistance in rats with nonalcoholic fatty liver disease (NAFLD)...

2022-09-19
【Animal modeling】-Effect of astragaloside IV on inflammatory factors and ultrastructure in cerebral ischemia-reperfusion rats

【Animal modeling】-Effect of astragaloside IV on inflammatory factors and ultrastructure in cerebral ischemia-reperfusion rats

To observe the effect of astragaloside IV on inflammatory factors and ultrastructure in cerebral ischemia-reperfusion rats...

2022-09-19
【Animal Modeling】-Hydrogen peroxide-induced changes in isolated rat uterine ligament fibroblasts

【Animal Modeling】-Hydrogen peroxide-induced changes in isolated rat uterine ligament fibroblasts

To investigate the effect and possible mechanism of oxidative stress on the proliferation, apoptosis, collagen synthesis and inflammatory factor expression of uterine ligament fibroblasts...

2022-09-19
【Animal Modeling】-Study reveals that chlorothalonil affects the survival and gut microbial diversity of bee larvae

【Animal Modeling】-Study reveals that chlorothalonil affects the survival and gut microbial diversity of bee larvae

Recently, a research team from the Institute of Honey Bee Research, Chinese Academy of Agricultural Sciences found that high exposure doses of the fungicide chlorothalonil reduced the survival rate of indoor artificially reared bee larvae, changed th...

2022-09-19