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【Animal modeling】-Protease inhibitor on the conditions of rat Parkinson\'s disease modeling

【Animal modeling】-Protease inhibitor on the conditions of rat Parkinson's disease modeling

To observe the effects of different doses of protease inhibitors on rat behavior and the expression of tyrosine hydroxylase and α-synuclein in the substantia nigra, and to explore the optimal conditions for a chronic model of PSI-induced Parkinson\'s...

2022-09-05
【Animal modeling】-Construction and evaluation of doxorubicin-induced chronic cardiotoxicity model in mice

【Animal modeling】-Construction and evaluation of doxorubicin-induced chronic cardiotoxicity model in mice

To evaluate the modeling effect of different concentrations of doxorubicin-induced cardiotoxicity model in mice based on pathological changes...

2022-09-05
【Animal Modeling】- Overexpression of LAMP2A in the substantia nigra improves motor function in a rhesus monkey model of Parkinson\'s disease

【Animal Modeling】- Overexpression of LAMP2A in the substantia nigra improves motor function in a rhesus monkey model of Parkinson's disease

To observe the effect of substantia nigra overexpressing lysosome-associated membrane protein 2A up-regulating molecular chaperone-mediated autophagy on the motor behavior of experimental monkeys in a rhesus monkey model of Parkinson\'s disease...

2022-09-05
【Animal Modeling】-Establishment and evaluation of an animal model of Alzheimer\'s disease-phlegm-stasis syndrome combination

【Animal Modeling】-Establishment and evaluation of an animal model of Alzheimer's disease-phlegm-stasis syndrome combination

The purpose of this study is to explore the establishment of a reliable disease-syndrome combination animal model of Alzheimer\'s disease and phlegm-stasis syndrome, to provide a corresponding animal model for the prevention and treatment of AD with ...

2022-09-05
【Animal Modeling】-High-fat and high-sugar diet-induced changes in intestinal flora in Wuzhishan miniature pig atherosclerosis model

【Animal Modeling】-High-fat and high-sugar diet-induced changes in intestinal flora in Wuzhishan miniature pig atherosclerosis model

To observe the changes of intestinal flora in Wuzhishan miniature pig atherosclerosis model induced by high-fat and high-sugar diet...

2022-09-05
【Animal Modeling】-Research progress on artificially assisted reproductive technology and genetic modification models of marmosets

【Animal Modeling】-Research progress on artificially assisted reproductive technology and genetic modification models of marmosets

The common cotton-eared marmoset is a small non-human primate experimental animal. It has the advantages of low feeding cost, high reproductive efficiency, and short sexual maturity. It is very suitable for assisted reproductive technology and geneti...

2022-09-02
【Animal Modeling】-Establishment of rat gastritis-carcinoma transformation model and exploration of early diagnosis methods

【Animal Modeling】-Establishment of rat gastritis-carcinoma transformation model and exploration of early diagnosis methods

To construct a rat model of gastritis-carcinoma transformation, and to explore new serological indicators for early gastric cancer...

2022-09-02
【Animal Modeling】-Establishment and mechanism of high-fat and high-salt diet-induced hypertension model in Bama miniature pigs

【Animal Modeling】-Establishment and mechanism of high-fat and high-salt diet-induced hypertension model in Bama miniature pigs

To establish a hypertensive model of Bama miniature pigs with a high-fat and high-salt diet, and to explore its possible pathogenesis...

2022-09-02
【Animal Modeling】-Experimental Study on Establishing a Mouse Model of Hyperuricemia Kidney Damage

【Animal Modeling】-Experimental Study on Establishing a Mouse Model of Hyperuricemia Kidney Damage

To establish a reasonable and stable mouse model of hyperuricemia nephropathy, and to provide a pathological model for screening and researching drugs for the treatment of hyperuricemia nephropathy...

2022-09-02
Early mouse embryonic stem cell models are more accurate

Early mouse embryonic stem cell models are more accurate

Scientists at the Hub Hubrecht Institute (KNAW) and Cambridge University (UK) have successfully produced complex embryo-like structures from mouse embryonic stem cells. These structures, called gastric colloids, allow the ovaries to grow for the firs...

2022-09-02
【Animal Modeling】-Effects of propofol on tumor lung metastasis and the expression of MTA1 and Wnt1 in tumor-bearing rats

【Animal Modeling】-Effects of propofol on tumor lung metastasis and the expression of MTA1 and Wnt1 in tumor-bearing rats

To investigate the effect of different doses of propofol on the expression of MTA1 and Wnt1 in rat MADB106 cells lung metastasis and tumor tissue...

2022-09-02
【Animal Modeling】-Research on the relationship between tree shrew gallstone model and substance P in digestive tract

【Animal Modeling】-Research on the relationship between tree shrew gallstone model and substance P in digestive tract

To investigate the relationship between the establishment of tree shrew gallstone model and substance P by feeding tree shrew with high cholesterol diet...

2022-09-02
【Animal modeling】-Effect of paclitaxel on the expression of CD28, CTLA-4 and BAFF in experimental autoimmune encephalomyelitis rats

【Animal modeling】-Effect of paclitaxel on the expression of CD28, CTLA-4 and BAFF in experimental autoimmune encephalomyelitis rats

To investigate the effect of paclitaxel on the expression of CD28 and CTLA-4 in the brain tissue of rats with experimental autoimmune encephalomyelitis and the content of B cell stimulating factor (BAFF) in the supernatant of spleen tissue and its si...

2022-09-02
【Animal Modeling】-Research on the standard of abnormal toxicity of Asarum injection preparations detected by mice

【Animal Modeling】-Research on the standard of abnormal toxicity of Asarum injection preparations detected by mice

To determine the LD50 value of mice intravenously administered with Asarum injection preparation, and to draft the abnormal toxicity inspection standard of this product...

2022-09-02
【Animal Modeling】-Changes and significance of metallothionein expression in the development of hepatocellular carcinoma in C57BL/6J mice

【Animal Modeling】-Changes and significance of metallothionein expression in the development of hepatocellular carcinoma in C57BL/6J mice

To understand the dynamic changes and regularities of gene expression levels of metallothioneins (MTs) in the development of mouse hepatocellular carcinoma (HCC), and to explore the significance of MTs in the development of HCC...

2022-09-02
【Animal Modeling】-Vitamin C enhances the proliferation of BMSCs derived from aging individuals in SAMP6 mice

【Animal Modeling】-Vitamin C enhances the proliferation of BMSCs derived from aging individuals in SAMP6 mice

To observe whether vitamin C (Vc) can promote the proliferation of bone marrow mesenchymal stem cells (BMMSCs) derived from aging individuals by increasing telomerase activity...

2022-09-02