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【Animal Modeling】-Changes in the structure and function of the immune system of SD rats during natural aging

【Animal Modeling】-Changes in the structure and function of the immune system of SD rats during natural aging

To observe the changes in the structure and function of the immune system in naturally aged SD rats, and to explore the possible mechanisms?...

2022-05-17
【Animal modeling】-The treatment and mechanism of hemin on gestational hypertensive rats

【Animal modeling】-The treatment and mechanism of hemin on gestational hypertensive rats

To preliminarily explore the therapeutic effect and possible regulatory mechanism of heme oxygenase inducer hemin (Hemin) in rats with pregnancy-induced hypertension (HDCP)...

2022-05-17
【Animal Modeling】-The effect of cardiosphere-derived myocardial stem cells combined with ventricular extracellular matrix in the treatment of acute myocardial infarction in rats

【Animal Modeling】-The effect of cardiosphere-derived myocardial stem cells combined with ventricular extracellular matrix in the treatment of acute myocardial infarction in rats

To study whether ventricular extracellular matrix (ECM) can promote the differentiation of cardiomyocyte-derived cardiac stem cells (CDC) implanted into myocardial tissue of myocardial infarction into cardiomyocytes, vascular endothelial and vascular...

2022-05-17
【Animal modeling】-The role of up-regulation of p-CaMKⅡ expression in dorsal root ganglion in rats with diabetic neuralgia

【Animal modeling】-The role of up-regulation of p-CaMKⅡ expression in dorsal root ganglion in rats with diabetic neuralgia

To observe the expression of phosphorylated calcineurin II (p-CaMK II) in the dorsal root ganglia of diabetic neuropathic pain model rats at different stages...

2022-05-17
【Animal Modeling】-Effects of histamine on motor desire and spatial memory in depressed rats

【Animal Modeling】-Effects of histamine on motor desire and spatial memory in depressed rats

Taking SD rats as the research object, to explore the effect of histamine on neurons in the hippocampal C1 area and the behavior of depression rats?...

2022-05-17
【Animal Modeling】-Construction and Preliminary Phenotypic Analysis of Lymphocyte Activation Gene  ̄3 Knockout (Lag ̄3-/-) Mice

【Animal Modeling】-Construction and Preliminary Phenotypic Analysis of Lymphocyte Activation Gene  ̄3 Knockout (Lag ̄3-/-) Mice

To construct lymphocyte activation gene  ̄3 (Lag ̄3) knockout mice, and to preliminarily analyze the effect of Lag ̄3 gene knockout on the phenotype of mice, so as to provide an animal model for subsequent in vivo functional studies of Lag ̄3...

2022-05-17
【Animal modeling】-Optimization of dose-response relationship between N-ethyl-N-nitrosourea and cyclophosphamide in pig-a gene mutation test in rats

【Animal modeling】-Optimization of dose-response relationship between N-ethyl-N-nitrosourea and cyclophosphamide in pig-a gene mutation test in rats

To study the effect of different doses of N-ethyl-N-nitrosourea (ENU) and cyclophosphamide (CP) on the deletion rate of ankyrin CD59 on the peripheral blood red blood cell surface of SD rats, and to optimize the Pig-a gene mutation test Detection met...

2022-05-17
【Animal modeling】-Combined with high-resolution MRI and micro-CT to evaluate the repairing effect of Taohong Siwu Decoction on femoral head necrosis in rabbits

【Animal modeling】-Combined with high-resolution MRI and micro-CT to evaluate the repairing effect of Taohong Siwu Decoction on femoral head necrosis in rabbits

To establish a rabbit model of steroid-induced necrosis of the femoral head, and to evaluate the repairing effect of Taohong Siwu Decoction (THSWD) on the microscopic bone structure damage of SIONFH combined with high-resolution MRI and micro-CT...

2022-05-17
【Animal Modeling】-Effects of intraperitoneal injection of human tumor cells into fetal mice in pregnant mice on the growth and development of fetal mice

【Animal Modeling】-Effects of intraperitoneal injection of human tumor cells into fetal mice in pregnant mice on the growth and development of fetal mice

To investigate the effect of intraperitoneal injection of human tumor HepG2 cells on fetal mouse growth and development in pregnant mice...

2022-05-17
【Animal Modeling】-The effect of icariin on experimental IgA nephropathy in rats and related mechanisms

【Animal Modeling】-The effect of icariin on experimental IgA nephropathy in rats and related mechanisms

To explore the effects of different doses of icariin on rats with experimental IgA nephropathy, and to study its related mechanism...

2022-05-17
【Animal Modeling】-CBA/CaJ Mice Organ Weight, Blood Physiological and Biochemical Indexes and Immune Cell Proportion

【Animal Modeling】-CBA/CaJ Mice Organ Weight, Blood Physiological and Biochemical Indexes and Immune Cell Proportion

To determine the basic biological indicators of SPF CBA/CaJ mice, and to lay a foundation for better use of this strain of mice for biomedical research...

2022-05-16
【Animal modeling】-Polymorphism analysis of PPARγ2 gene promoter in Wuzhishan miniature pigs

【Animal modeling】-Polymorphism analysis of PPARγ2 gene promoter in Wuzhishan miniature pigs

To analyze the polymorphisms in the regulatory region of the PPARγ2 gene promoter in Wuzhishan miniature pigs...

2022-05-16
【Animal Modeling】-Analysis of Bacterial Community Diversity in Large Intestine Contents of Tree Shrews

【Animal Modeling】-Analysis of Bacterial Community Diversity in Large Intestine Contents of Tree Shrews

To analyze the structure and composition of E. coli bacteria in tree shrew by high-throughput sequencing technology...

2022-05-16
【Animal Modeling】-improved New Zealand Rabbit Common Carotid Artery Cannulation Fixation Method

【Animal Modeling】-improved New Zealand Rabbit Common Carotid Artery Cannulation Fixation Method

To investigate a stable, not easy to fall off, and continuous and timed blood collection method for the common carotid artery cannulation of New Zealand rabbits...

2022-05-16
【Animal Modeling】-Evaluation of the Operational Effect of Animal Nasal Aerosol Exposure Device

【Animal Modeling】-Evaluation of the Operational Effect of Animal Nasal Aerosol Exposure Device

The purpose of this study is to investigate whether the animal nasal aerosol exposure device can operate normally and generate aerosol particles with a specific particle size, and to explore the air tightness, distribution uniformity and disinfection...

2022-05-16
【Animal Modeling】-Screening and application of single nucleotide polymorphism markers for identification of four commonly used strains of rats

【Animal Modeling】-Screening and application of single nucleotide polymorphism markers for identification of four commonly used strains of rats

To screen out the single nucleosides that can rapidly identify four commonly used rat strains [Wistar rat, Goto-Kakizaki (GK) rat, Brown-Norway (BN) rat, Sprague-Dawley (SD) rat] acid polymorphism sites and verify their reliability...

2022-05-16