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The incidence of prostate cancer model caused by the combination of chemical carcinogen DMAB and long-acting testosterone propionate (TP) is high. The cancer originates from the dorsal and middle lobe, and it has homology with cancer....
2022-02-03Removal of the right kidney and clamping of the left renal artery can cause renal ischemic mitochondrial dysfunction and produce large amounts of hypoxanthine. In the hypoxic state, hypoxanthine cannot be metabolized into xanthine and accumulate in l...
2022-02-03The chemical carcinogens are directly applied to the tissues through local embedding and other methods. These carcinogens act on the surface epithelium of the ovary and cause cell transformation. At the same time, it is also possible to change the go...
2022-02-03The gene knockout mouse model uses transgenic technology to artificially knock out related genes that inhibit tumor occurrence, development and metastasis, and eliminates homologous recombination and Cre/loxP-induced conditional knockout system metho...
2022-02-03Renal vein ligation can lead to renal ischemia, renal tubular injury, ischemic atrophy and renal tubular loss, renal interstitial hyperplasia and tubular interstitial fibrosis (TIF) [Modeling method: weight 200-250 grams, weight percentage Anesthetiz...
2022-02-03Acute ischemia delays the conduction of impulse in the atrial ischemic area, making reentry easy to form, leading to the occurrence of atrial fibrillation...
2022-02-03The animal model of chronic myocardial ischemia is the gradual occlusion or stenosis of coronary arteries, which gradually causes myocardial ischemia to form ischemic cardiomyopathy. It is more consistent with the clinical pathophysiological process,...
2022-02-03Since Rygaard and Povlsen first successfully transplanted excised human cancer tissue specimens into nude mice in 1969, the transplanted tumor models have been widely used in tumor growth and metastasis research. .. Common methods for establishing CR...
2022-02-03Chronic bronchitis (chronic bronchitis) refers to chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues caused by infectious or non-infectious factors. The pathological features of chronic bronchitis are bronchial...
2022-02-03Bleomycin is a peptide antitumor drug. The mechanism of pulmonary fibrosis is mainly due to the action of reactive oxygen species. In the early stage of bleomycin lung injury, that is, the alveolitis stage, a large amount of oxygen free radicals are...
2022-02-03Large doses of adrenaline directly stimulate beta receptors, increase cardiac autonomy, conductivity, hypersensitivity, etc., and cause arrhythmia (ventricular premature beats, ventricular tachycardia, and even ventricular fibrillation). Even movemen...
2022-02-03When an allergen (usually used ovalbumin) is injected into a guinea pig, its soluble antigen component will stimulate the body to produce IgE, which leads to an allergic state. When the animal comes into contact with the antigen again, the antigen-an...
2022-02-03By ligating the coronary arteries of the model animals, the coronary arteries become narrowed or occluded, and the myocardium supplied from the coronary arteries is ischemia or necrosis, thereby causing myocardial infarction in the model animals...
2022-02-03Myocardial ischemia is a state in which the supply of the heart decreases when the blood perfusion of the heart is reduced, the energy metabolism of the myocardium is abnormal and normal heart function cannot be maintained...
2022-02-03Studies have shown that the vagus nervous system may be involved in the formation and maintenance of atrial fibrillation, especially it is closely related to atrial fibrillation caused by pulmonary veins...
2022-02-03The rapid atrial pacing atrial fibrillation model is currently the most studied and most widely used animal model of chronic atrial fibrillation. This mechanism is related to electrical and structural remodeling caused by rapid atrial pacing...
2022-02-03