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Caerulein is an analog of cholecystokinin (CCK). Cholecystokinin is a polypeptide hormone composed of 33 amino acids. Its main physiological function is to stimulate the contraction of the gallbladder and the relaxation of the Oddi sphincter, promote...
2022-02-02The lateral hydraulic shock brain injury model involves the rapid injection of a certain amount of normal saline into the cranial cavity, causing deformation and displacement of the brain tissue...
2022-02-02Pancreatic cancer is a highly malignant tumor with a poor prognosis. Pancreatic cancer is insidious, difficult to diagnose early, and is prone to liver metastasis, peritoneal spread or local recurrence, and insensitivity to chemotherapy drugs...
2022-02-02The researchers transplanted human liver cells into immunodeficient mice and allowed them to grow in the mice, gradually forming a human-mouse chimeric liver. In this animal model, HBV can survive in human liver cells and be humanized, mouse hepatiti...
2022-02-02Acetaldehyde is an intermediate metabolite of ethanol, which directly damages the liver and converts coenzyme I (NAD) into reduced coenzyme I (NADH) in the liver, thereby reducing the ratio of NAD/NADH. It inhibits the tricarboxylic acid cycle, and t...
2022-02-02By blocking the bile duct or injecting sclerosing agent, the extrahepatic bile duct is artificially blocked, causing the bile duct to expand above the blocked site, cholestasis, and increasing the pressure of the bile duct. I will. Intrahepatic blood...
2022-02-02Methionine-choline deficiency (MCD) diets are commonly used to induce classic NAFLD animal models. MCD diet is rich in carbohydrates (40%) and fat (10%), but lacks methionine and choline, which are involved in the oxidation of fatty acid β in liver c...
2022-02-02The benchmark behavior evaluation of the learning and memory abilities of rodent AD models was mainly tested in the Morris water maze experimental system....
2022-02-02Kawai\\\'s test method is to create a 30 cm x 30 cm x 15 cm plexiglass box with a 6 cm x 6 cm grid engraved on the bottom, and test in a quiet low light environment. After allowing the animal to adapt to the environment for 10 minutes, calculate the ...
2022-02-02With the development of the transportation and construction industry, the emergence of accidents and natural disasters, the incidence of traumatic brain injury (TBI) is gradually increasing. Traumatic brain injury ranks first among the causes of deat...
2022-02-02Liver cancer model formed by transplanting animal or human liver cancer tissues, cell lines and other malignant tumors into animals...
2022-02-02ApoE- can create ob/ob mice + MCD diet, db/db mice + MCD diet, Abcb11 mice + MCD diet and other animal models by combining genetic modification and nutritional factors according to the rules of human NAFLD. /-Mouse + HFD, PPARa-/-mouse + MCD diet, et...
2022-02-02Key gene mutations in fat metabolism in liver cells can cause abnormal fat metabolism and disrupt the balance of fat input/output in the liver...
2022-02-02Generally, methylnitrosonitroguanidine (N-methyl-N\\\'-nitrosonitroguanidine, MNNG) and methylcholestene (MC) are used. MNNG is a kind of polycyclic hydrocarbon, which has a strong carcinogenic effect and can cause the production of nitric oxide in t...
2022-02-02Cysteamine, also known as β-mercaptoethylamine, can specifically consume the body\\\'s somatostatin. It is also called a somatostatin depletion agent. D-cell damage to the duodenal mucosa may be one of the targets of the selective action of cysteamin...
2022-02-02Replication method Adult rats are injected intraperitoneally with 100 mg/kg body weight of thioacetamide (TAA), the initial dose is doubled, and then every other week for 13 weeks...
2022-02-02