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【Animal Modeling】-The effect of Huangqi injection on the mRNA expression of IL-1β, MCP-1 and TNF-α in the kidney of db/db mice

【Animal Modeling】-The effect of Huangqi injection on the mRNA expression of IL-1β, MCP-1 and TNF-α in the kidney of db/db mice

To investigate the regulatory effect of Huangqi injection on immune cells and inflammatory factors in db/db mice and its possible mechanism...

2022-01-05
【Animal Modeling】-The pharmacological model of delayed depolarization of cardiomyocytes and triggering arrhythmia

【Animal Modeling】-The pharmacological model of delayed depolarization of cardiomyocytes and triggering arrhythmia

The guinea pig weighing 200~300g was stunned with a blunt instrument, and the heart was quickly taken out. In the oxygen-rich Tris-Tai\\\\\\\'s solution (NaCl 137mmol/L, KCl 5.4mmol/L, CaCl22.3mmol/L, MgCl21.05mmol/L) , NaHCO31.2mmol/L...

2022-01-05
[Animal Modeling]-Rabbit scald model

[Animal Modeling]-Rabbit scald model

Copy method The day before the experiment, use 2.5g of experimental rabbits with 100g/L sodium sulfide, 12 hours before fasting and drinking. After general anesthesia and inhalation of ether, the rat’s back and torso were immersed in 95°C constant te...

2022-01-05
【Animal Modeling】-Why build an animal model of depression?

【Animal Modeling】-Why build an animal model of depression?

Depression is a common mental illness, its main symptoms are depression and loss of interest...

2022-01-05
【Animal Modeling】-Animal Model of Transplantable Tumor

【Animal Modeling】-Animal Model of Transplantable Tumor

The blood samples of clinical leukemia patients cultured and passaged in the abdominal cavity of mice, bone marrow samples or non-solid tumor ascites samples are equal amounts of balanced salt solution (PBS, etc.)...

2022-01-05
【Animal Modeling】-animal model of cervical spine mechanical imbalance

【Animal Modeling】-animal model of cervical spine mechanical imbalance

Copy method After cutting and washing the rabbit’s neck, the rabbit was anesthetized intramuscularly with ketamine at a dose of 0.1 g/kg body weight; after sufficient anesthesia, it was fixed on the operating table in a lying position. , Then spread...

2022-01-05
How to create immunodeficient mice? -【Animal Modeling】

How to create immunodeficient mice? -【Animal Modeling】

The establishment of highly immunodeficient mice provides important tools and guarantees for the clinical treatment of human tumors...

2022-01-05
【Animal Modeling】-Nerve Root Animal Model

【Animal Modeling】-Nerve Root Animal Model

Mechanical compression of nerve roots is not really directly related to the development of this disease. Inflammation of nerve roots, malnutrition and impaired conduction properties are equally important....

2022-01-05
【Animal Modeling】-animal model of traction retinal detachment

【Animal Modeling】-animal model of traction retinal detachment

Replication method (1) Rabbit skin fibroblast culture: Take a New Zealand rabbit weighing about 2 kg, shave off one of the buttocks, and disinfect the skin with 75% ethanol...

2022-01-05
[Animal modeling]-Changes in the morphology of the retina and the expression of RhoA and ROCK-2 in rats with ocular ischemic syndrome

[Animal modeling]-Changes in the morphology of the retina and the expression of RhoA and ROCK-2 in rats with ocular ischemic syndrome

To establish a rat model of ocular ischemic syndrome (OIS) to observe the morphology of the retina and the expression of RhoA and ROCK-2 in the rat retina after ischemia...

2022-01-05
【Animal Modeling】-Establishment of in vitro apoptosis model of rat intervertebral disc nucleus pulposus cells

【Animal Modeling】-Establishment of in vitro apoptosis model of rat intervertebral disc nucleus pulposus cells

Establishment of an in vitro apoptosis model of rat nucleus pulposus cells...

2022-01-05
【Animal Modeling】-The effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

【Animal Modeling】-The effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia

Explore the effect and mechanism of Shenqu Xiaoshi oral liquid on gastrointestinal motility in mice with functional dyspepsia (FD)...

2022-01-04
【Animal Modeling】-Paeoniflorin improves Bayk8644-induced depression and anxiety-like behavior in rats and its mechanism

【Animal Modeling】-Paeoniflorin improves Bayk8644-induced depression and anxiety-like behavior in rats and its mechanism

To explore the pharmacological mechanism of paeoniflorin in improving depression and anxiety-like behaviors in rats based on L-type voltage-dependent calcium channels...

2022-01-04
【Animal Modeling】-Study on the protective effect of resveratrol on renal injury in preeclamptic rats based on the LIGHT/HVEM pathway

【Animal Modeling】-Study on the protective effect of resveratrol on renal injury in preeclamptic rats based on the LIGHT/HVEM pathway

To explore the effect of resveratrol (RSV) on the lymphotoxin analogue (LIGHT) / herpes virus interventional body (HVEM) pathway in preeclampsia (PE) rats and its protective effect on kidney injury...

2022-01-04
【Animal Modeling】-Leptin receptor knockout causes activation of rat brain microglia

【Animal Modeling】-Leptin receptor knockout causes activation of rat brain microglia

This article uses leptin receptor (LEPR) knockout rats to analyze the changes in the morphology and function of microglia in the rat brain after leptin receptor gene knockout, and explore the functional role of leptin receptors in microglia...

2022-01-04
【Animal Modeling】-Experimental Study of Puerarin on Alleviating Radiation-induced Acute Intestinal Mucosal Damage in Rats

【Animal Modeling】-Experimental Study of Puerarin on Alleviating Radiation-induced Acute Intestinal Mucosal Damage in Rats

To study the protective effect of puerarin on the intestinal mucosal damage of SD rats induced by radiation and its molecular mechanism...

2022-01-04
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