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【Animal Modeling】-Therapeutic effect of rapamycin on DDC-induced primary sclerosing cholangitis in mice

【Animal Modeling】-Therapeutic effect of rapamycin on DDC-induced primary sclerosing cholangitis in mice

To explore the therapeutic effect of rapamycin on primary sclerosing cholangitis (PSC) in mice induced by 3,5-diethoxycarbonyl 1,4-dihydrocollidine (DDC), and explore its potential mechanism...

2022-01-04
【Animal Modeling】-Acupuncture can improve the symptoms of insomnia rats by regulating GABA-Gln metabolism and its influence on spontaneous activities

【Animal Modeling】-Acupuncture can improve the symptoms of insomnia rats by regulating GABA-Gln metabolism and its influence on spontaneous activities

To study the improvement of acupuncture on the symptoms of insomnia rats and its influence on spontaneous activities, and to explore its possible mechanism...

2022-01-04
【Animal Modeling】-The inhibitory effect of cytomegalovirus on some immune indexes of mice implanted with polymethyl methacrylate

【Animal Modeling】-The inhibitory effect of cytomegalovirus on some immune indexes of mice implanted with polymethyl methacrylate

To study the inhibitory effect of cytomegalovirus (CMV) on the immune response of mice implanted with polymethyl methacrylate (PMMA)....

2022-01-04
【Animal Modeling】-Experimental Study on Rat Lung Tissue Damage Induced by Dental Grinding Dust

【Animal Modeling】-Experimental Study on Rat Lung Tissue Damage Induced by Dental Grinding Dust

To evaluate the effects of cobalt, chromium and molybdenum metal (trade name: Vitalin), zirconium dioxide porcelain, and polymethyl methacrylate resin three kinds of dental grinding dust on lung tissue damage in rats...

2021-12-31
Animal experiment of new diabetes drug succeeded

Animal experiment of new diabetes drug succeeded

\\\\\\\"One injection should last at least four months.\\\\\\\" A research team in the United States has developed a new drug to control blood sugar and has achieved success in animal studies....

2021-12-31
[Animal Modeling]-Effect of Naoshuantong Capsules on the Expression of Inflammatory Factors in ApoE-/- Mice

[Animal Modeling]-Effect of Naoshuantong Capsules on the Expression of Inflammatory Factors in ApoE-/- Mice

To observe the effects of Naoshuantong Capsules on the inflammation-related factors interleukin-1β (interleukin-1 beta, IL-1β), interleukin-6 (interleukin-6, IL-6) and tumors in ApoE-/- atherosclerosis mouse model. Necrosis factor (tumor necrosis fac...

2021-12-31
【Animal Modeling】-Hydrogen peroxide induces related changes in rat uterine ligament fibroblasts in vitro

【Animal Modeling】-Hydrogen peroxide induces related changes in rat uterine ligament fibroblasts in vitro

To explore the effects of oxidative stress on the proliferation, apoptosis, collagen synthesis and expression of inflammatory factors in uterine ligament fibroblasts and possible mechanisms...

2021-12-31
[Animal Modeling]-Changes and Significance of Arterial Blood Gas Analysis Indexes in Rats with Chronic Hypoxic Pulmonary Hypertension

[Animal Modeling]-Changes and Significance of Arterial Blood Gas Analysis Indexes in Rats with Chronic Hypoxic Pulmonary Hypertension

To investigate the changes and significance of arterial blood gas analysis indexes in a rat model of hypoxic pulmonary hypertension induced by chronic hypoxia...

2021-12-31
【Animal Modeling】-Protective effect of estrogen on oxidative stress damage of mouse osteoblast MC3T3-E1 and its mechanism

【Animal Modeling】-Protective effect of estrogen on oxidative stress damage of mouse osteoblast MC3T3-E1 and its mechanism

To explore the protective effect and mechanism of estrogen on oxidative stress injury of mouse osteoblast MC3T3-E1...

2021-12-31
[Animal modeling]-Increased serotonin can prevent mice from becoming addicted to cocaine

[Animal modeling]-Increased serotonin can prevent mice from becoming addicted to cocaine

Researchers report that elevated serotonin levels can prevent mice from compulsive seeking and addiction to cocaine...

2021-12-31
[Animal Modeling]-Emphysema animal model

[Animal Modeling]-Emphysema animal model

The solution is placed in a sealed reproductive method test guinea pig (male or female) ventilated isolation bag, then exposed to tobacco smoke, daily (10 rows/time, once/day, 5D)/1 week, 1, 3, 6, and 12 Month, lung histopathology and lung function t...

2021-12-31
【Animal Modeling】-Effects of Oct4 and Cdx2 on the differentiation of inner cell mass and trophectoderm of bovine embryo

【Animal Modeling】-Effects of Oct4 and Cdx2 on the differentiation of inner cell mass and trophectoderm of bovine embryo

Objective To study the effects of Oct4 and Cdx2 knockdown on the expression of genes related to the differentiation of bovine ICM and TE, and to explain the role of Oct4 and Cdx2 in the early development of bovine embryos...

2021-12-31
【Animal Modeling】-The effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in rats with fulminant liver failure

【Animal Modeling】-The effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in rats with fulminant liver failure

 Objective To explore the effect of alprostadil (PGE1) on liver function in rats with fulminant hepatic failure (FHF), and to explore its effect on eukaryotic translation initiation factor 2α (eIF2α) / activating transcription factor 4 (ATF4) / C/ EB...

2021-12-31
[Animal Modeling]-Ke Shan Ting regulates skin inflammation and autophagy in mice with psoriasis by inhibiting C5a/C5aR1 pathway

[Animal Modeling]-Ke Shan Ting regulates skin inflammation and autophagy in mice with psoriasis by inhibiting C5a/C5aR1 pathway

This study intends to use imiquimod (IMQ) mouse psoriasis model to explore the regulation effect of Cosentyx on skin inflammation and autophagy in psoriasis mice through the C5a / C5aR1 pathway...

2021-12-31
【Animal Modeling】-The effect of salidroside on Nrf2/Keap1 signaling pathway and wound healing in rats with diabetic foot ulcer

【Animal Modeling】-The effect of salidroside on Nrf2/Keap1 signaling pathway and wound healing in rats with diabetic foot ulcer

Objective To explore the effects of salidroside (Sal) on the nuclear transcription factor E2 related factor 2 / Kelch-like epichlorohydrin related protein 1 (Nrf2 / Keap1) signaling pathway and wound healing in rats with diabetic foot ulcer (DFU)...

2021-12-31
【Animal Modeling】-Cyno-eating monkey muscle atrophy model

【Animal Modeling】-Cyno-eating monkey muscle atrophy model

Establish an animal model of cynomolgus muscle atrophy, and use the method of restricting the movement of the lower limbs to establish a model evaluation method?...

2021-12-30