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【Animal modeling】-The regulatory effect of Quqi powder on telomerase activity in precancerous lesions of liver cancer

【Animal modeling】-The regulatory effect of Quqi powder on telomerase activity in precancerous lesions of liver cancer

To investigate the role of telomerase in the formation and development of precancerous lesions of hepatocellular carcinoma and the regulation mechanism of the prescription mistletoe powder (HQS) and the monarch drug mistletoe on its activity...

2022-05-18
【Animal modeling】-plasma lipidomic characteristics of spontaneously obese rhesus monkeys

【Animal modeling】-plasma lipidomic characteristics of spontaneously obese rhesus monkeys

The increasing prevalence of obesity is becoming a medical and public health concern as obesity is closely associated with metabolic abnormalities including hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and cardiovas...

2022-05-18
【Animal modeling】-Exploration of the protective effect of bifidobacteria on liver function in rats with chronic alcoholic liver injury

【Animal modeling】-Exploration of the protective effect of bifidobacteria on liver function in rats with chronic alcoholic liver injury

To investigate the protective or influence of bifidobacteria on liver function in rats with chronic alcoholic liver injury, and to explore its mechanism preliminarily...

2022-05-18
【Animal Modeling】-Efficacy and safety of electroacupuncture combined with methylprednisolone on intervertebral disc prolapse in rats

【Animal Modeling】-Efficacy and safety of electroacupuncture combined with methylprednisolone on intervertebral disc prolapse in rats

To observe the effects of electroacupuncture combined with methylprednisolone and electroacupuncture or methylprednisolone alone on limb motor function and neuronal Nissl bodies in a rat model 24 hours after intervertebral disc prolapse, and to provi...

2022-05-18
【Animal modeling】-Construction of MiR-31 transgenic mice and its expression in tissues and organs

【Animal modeling】-Construction of MiR-31 transgenic mice and its expression in tissues and organs

To construct stably overexpressed miR-31 transgenic mice, to detect the expression changes of miR-31 in major tissues and organs, and to provide qualified tool mice for the application of miR-31 overexpression in vivo...

2022-05-18
【Animal Modeling】-Effect of Mac-1 gene deletion on the growth of melanoma

【Animal Modeling】-Effect of Mac-1 gene deletion on the growth of melanoma

To investigate the effect of Mac-1 deletion on melanoma tumor growth...

2022-05-18
【Animal Modeling】-Relevant mechanism of hypertonic saline protecting blood-brain barrier and reducing cerebral edema in rats with cerebral hemorrhage

【Animal Modeling】-Relevant mechanism of hypertonic saline protecting blood-brain barrier and reducing cerebral edema in rats with cerebral hemorrhage

To investigate the related mechanism of hypertonic saline treatment in reducing cerebral edema in rats with cerebral hemorrhage...

2022-05-18
【Animal modeling】-Effect of Bcl-2 inhibitor on astragalus injection on reducing the apoptosis of hippocampal neurons in rats with hypoxia and hypoglycemia/reoxygenation and reglycemia

【Animal modeling】-Effect of Bcl-2 inhibitor on astragalus injection on reducing the apoptosis of hippocampal neurons in rats with hypoxia and hypoglycemia/reoxygenation and reglycemia

To investigate the effect of astragalus injection (AI) on the apoptosis of hippocampal neurons in hypoxia-hypoglycemia/reoxygenation and reglycemia (H/R) rats under the action of Bcl-2 inhibitor (TW-37)...

2022-05-18
【Animal modeling】-Effect of acute exercise on the expression of miRNA-30a in rat myocardium

【Animal modeling】-Effect of acute exercise on the expression of miRNA-30a in rat myocardium

To study the effect of acute exercise on myocardial miRNA-30a and the expression of autophagy-related genes in rats, and to explore the regulatory mechanism of miRNA-30a on myocardial autophagy activity in different recovery periods after exercise...

2022-05-18
【Animal modeling】-Guanxinning tablet inhibits myocardial cell apoptosis in chronic heart failure mice through PI3K/AKT signaling pathway

【Animal modeling】-Guanxinning tablet inhibits myocardial cell apoptosis in chronic heart failure mice through PI3K/AKT signaling pathway

To observe the therapeutic effect of Guanxinning Tablets on chronic heart failure (CHF) mice, and to explore its action pathway from myocardial cell apoptosis and related cell signaling pathways, so as to provide experimental basis for the clinical a...

2022-05-17
【Animal Modeling】-Changes in the structure and function of the immune system of SD rats during natural aging

【Animal Modeling】-Changes in the structure and function of the immune system of SD rats during natural aging

To observe the changes in the structure and function of the immune system in naturally aged SD rats, and to explore the possible mechanisms?...

2022-05-17
【Animal modeling】-The treatment and mechanism of hemin on gestational hypertensive rats

【Animal modeling】-The treatment and mechanism of hemin on gestational hypertensive rats

To preliminarily explore the therapeutic effect and possible regulatory mechanism of heme oxygenase inducer hemin (Hemin) in rats with pregnancy-induced hypertension (HDCP)...

2022-05-17
【Animal Modeling】-The effect of cardiosphere-derived myocardial stem cells combined with ventricular extracellular matrix in the treatment of acute myocardial infarction in rats

【Animal Modeling】-The effect of cardiosphere-derived myocardial stem cells combined with ventricular extracellular matrix in the treatment of acute myocardial infarction in rats

To study whether ventricular extracellular matrix (ECM) can promote the differentiation of cardiomyocyte-derived cardiac stem cells (CDC) implanted into myocardial tissue of myocardial infarction into cardiomyocytes, vascular endothelial and vascular...

2022-05-17
【Animal modeling】-The role of up-regulation of p-CaMKⅡ expression in dorsal root ganglion in rats with diabetic neuralgia

【Animal modeling】-The role of up-regulation of p-CaMKⅡ expression in dorsal root ganglion in rats with diabetic neuralgia

To observe the expression of phosphorylated calcineurin II (p-CaMK II) in the dorsal root ganglia of diabetic neuropathic pain model rats at different stages...

2022-05-17
【Animal Modeling】-Effects of histamine on motor desire and spatial memory in depressed rats

【Animal Modeling】-Effects of histamine on motor desire and spatial memory in depressed rats

Taking SD rats as the research object, to explore the effect of histamine on neurons in the hippocampal C1 area and the behavior of depression rats?...

2022-05-17
【Animal Modeling】-Construction and Preliminary Phenotypic Analysis of Lymphocyte Activation Gene  ̄3 Knockout (Lag ̄3-/-) Mice

【Animal Modeling】-Construction and Preliminary Phenotypic Analysis of Lymphocyte Activation Gene  ̄3 Knockout (Lag ̄3-/-) Mice

To construct lymphocyte activation gene  ̄3 (Lag ̄3) knockout mice, and to preliminarily analyze the effect of Lag ̄3 gene knockout on the phenotype of mice, so as to provide an animal model for subsequent in vivo functional studies of Lag ̄3...

2022-05-17