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【Animal Modeling】-Safflower Yellow Pigment Protects the Kidneys of Mice with Diabetic Nephropathy and Its Mechanism

【Animal Modeling】-Safflower Yellow Pigment Protects the Kidneys of Mice with Diabetic Nephropathy and Its Mechanism

To investigate the renal protective effect and mechanism of safflower yellow on streptozotocin-induced diabetic nephropathy in mice...

2022-09-28
【Animal Modeling】-Protective effect of Patrinia on acetaminophen-induced drug-induced liver injury in rats

【Animal Modeling】-Protective effect of Patrinia on acetaminophen-induced drug-induced liver injury in rats

Paijiangcao is the whole rooted herb of the perennial herbs of the family Paiaceae, Huanghuabaijiang and Baihuabaijiang, with various pharmacological activities. The purpose of this study was to investigate the protective effect of Patrinia on acetam...

2022-09-28
【Animal Modeling】-Relevant mechanism of hypertonic saline protecting blood-brain barrier and reducing cerebral edema in rats with cerebral hemorrhage

【Animal Modeling】-Relevant mechanism of hypertonic saline protecting blood-brain barrier and reducing cerebral edema in rats with cerebral hemorrhage

To investigate the related mechanism of hypertonic saline treatment in reducing cerebral edema in rats with cerebral hemorrhage...

2022-09-27
【Animal modeling】-Dynamic changes of tumor-infiltrating immune cells in MC38 colon cancer mice

【Animal modeling】-Dynamic changes of tumor-infiltrating immune cells in MC38 colon cancer mice

To observe the dynamic changes of tumor-infiltrating immune cells during tumor development in tumor-bearing mice...

2022-09-27
【Animal modeling】-Intervention effect of chitosan on PM2.5-induced acute lung injury in mice

【Animal modeling】-Intervention effect of chitosan on PM2.5-induced acute lung injury in mice

To investigate the intervention effect of chitosan on PM2.5-induced acute lung injury in mice...

2022-09-27
【Animal modeling】-Effect of astragaloside Ⅱ on IL-21/STAT3 pathway and airway inflammation in juvenile asthmatic rats

【Animal modeling】-Effect of astragaloside Ⅱ on IL-21/STAT3 pathway and airway inflammation in juvenile asthmatic rats

To investigate the effect of astragaloside Ⅱ on the interleukin-21 ( IL-21 ) / signal transducer and activator of transcription 3 ( STAT3 ) pathway and airway inflammation in juvenile asthmatic rats...

2022-09-27
【Animal Modeling】-The effect of carbon tetrachloride-induced acute liver injury on the heart in a rat model

【Animal Modeling】-The effect of carbon tetrachloride-induced acute liver injury on the heart in a rat model

To investigate the effect of carbon tetrachloride on cardiac function and morphology in rats with acute liver injury...

2022-09-27
【Animal Modeling】-Study on the alleviation of exercise via FoxO1-lipophagy pathway. Study on hyperlipidemia in ApoE-/- mice

【Animal Modeling】-Study on the alleviation of exercise via FoxO1-lipophagy pathway. Study on hyperlipidemia in ApoE-/- mice

Lipophagy is a selective autophagy targeting adipose and is regulated by FoxO1. As an effective means of regulating lipid metabolism disorders, there is no report on whether exercise is related to FoxO1-lipophagy process in hyperlipidemia. In this st...

2022-09-27
【Animal Modeling】-NOD2 promotes the production of nitrosamine by diethyl nitrosamine to study the mechanism of inducing liver tissue inflammation in mice

【Animal Modeling】-NOD2 promotes the production of nitrosamine by diethyl nitrosamine to study the mechanism of inducing liver tissue inflammation in mice

To investigate the role and mechanism of NOD2, a pattern recognition receptor in hepatocytes, in the process of hepatic inflammation...

2022-09-27
【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

To study the expression of REST in corticosterone model mice and the effect of REST expression on depression and anxiety behavior in mice, and to explore its role in the mouse model of depression...

2022-09-27
【Animal Modeling】-Antibiotic-induced microbiome depletion promotes intestinal colonization of Campylobacter jejuni in mice

【Animal Modeling】-Antibiotic-induced microbiome depletion promotes intestinal colonization of Campylobacter jejuni in mice

To establish a method for intestinal colonization of C57BL/6 mice by Campylobacter jejuni through antibiotic-induced gut microbiome depletion...

2022-09-27
【Animal modeling】-Evaluation of the curative effect of Shenling Baizhu powder on ulcerative colitis model mice

【Animal modeling】-Evaluation of the curative effect of Shenling Baizhu powder on ulcerative colitis model mice

To explore the curative effect of Shenling Baizhu Powder on dextran sulfate sodium (DSS)-induced ulcerative colitis model mice...

2022-09-27
【Animal modeling】-Research on the intervention effect and mechanism of down-regulation of AQP-4 on cerebral ischemia-reperfusion injury model rats

【Animal modeling】-Research on the intervention effect and mechanism of down-regulation of AQP-4 on cerebral ischemia-reperfusion injury model rats

To explore the intervention effect and mechanism of down-regulation of AQP-4 on cerebral ischemia-reperfusion injury model rats...

2022-09-27
【Animal Modeling】-The effect and mechanism of betel nut on the antidepressant effect in mice

【Animal Modeling】-The effect and mechanism of betel nut on the antidepressant effect in mice

To study the effect of betel nut on depressive-like behavior in mice and its mechanism...

2022-09-27
【Animal Modeling】-Effect of Tongxinluo on the early lesions of calcific aortic valve disease in mice

【Animal Modeling】-Effect of Tongxinluo on the early lesions of calcific aortic valve disease in mice

To observe whether Tongxinluo intervention can delay the progression of calcific aortic valve disease in the early stage...

2022-09-27
【Animal Modeling】-Exploring the neuroprotective effect of DAHP on brain trauma rats based on NOS pathway

【Animal Modeling】-Exploring the neuroprotective effect of DAHP on brain trauma rats based on NOS pathway

To investigate the neuroprotective effect of 2,4-diamine-6-hydroxypyrimidine (DAHP) on traumatic brain injury rats, and to explore its possible mechanism...

2022-09-26