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【Animal modeling】-Effect of microcystin-LR on mitochondrial function of mouse primary hepatocytes

【Animal modeling】-Effect of microcystin-LR on mitochondrial function of mouse primary hepatocytes

Microcystin contamination caused by cyanobacterial blooms is one of the topics of concern worldwide. Microcystin LR (MC-LR) has strong specific hepatotoxicity, but the exact mechanism of its hepatic injury has not been fully elucidated...

2022-09-26
【Animal modeling】-Effect of paeoniflorin on intracellular Ca2+ in rat dorsal root neurons

【Animal modeling】-Effect of paeoniflorin on intracellular Ca2+ in rat dorsal root neurons

To establish a method to evaluate the effect of paeoniflorin on the concentration of free Ca2+ in rat dorsal root ganglion neurons...

2022-09-26
【Animal modeling】-Cloning of IFITM3 gene in African green monkey and its tissue-specific expression differences

【Animal modeling】-Cloning of IFITM3 gene in African green monkey and its tissue-specific expression differences

To study the function of interferon-induced transmembrane protein 3 in African green monkeys, as well as the mechanism and mode of its antiviral effect, the IFITM3 gene was cloned from different tissues and organs of African green monkeys, and the ex...

2022-09-26
【Animal Modeling】-Preliminary exploration of evaluating drug cardiotoxicity using cardiac-specific CYP2E1 gene-modified mice

【Animal Modeling】-Preliminary exploration of evaluating drug cardiotoxicity using cardiac-specific CYP2E1 gene-modified mice

To evaluate the cardiotoxicity of the drug sibutramine using two cardiac-specific CYP2E1 gene-modified mice, and to select an animal model with higher sensitivity in evaluating the cardiotoxicity of the drug...

2022-09-26
【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

To study the expression of REST in corticosterone model mice and the effect of REST expression on depression and anxiety behavior in mice, and to explore its role in the mouse model of depression...

2022-09-26
【Animal Modeling】-Manufacture and Application of Laser Localizer for Experimental Animal Magnetic Resonance Imaging System

【Animal Modeling】-Manufacture and Application of Laser Localizer for Experimental Animal Magnetic Resonance Imaging System

To design and develop a simple laser locator for rats and mice, and to provide a safe, convenient, accurate, low-cost and easy-to-operate experimental tool for medical nuclear magnetic resonance experiments...

2022-09-26
【Animal modeling】-Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

【Animal modeling】-Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

To investigate the effect of artificial recombinant botulinum toxin type A heavy chain (BoNT/A heavy chain) on the expression of local growth-related proteins in rats with spinal cord injury in vivo, and to provide a basis for elucidating the mechani...

2022-09-26
【Animal Modeling】-Minocycline inhibits the hyperpolarization-activated current of glial neurons in the dorsal horn of rat spinal cord

【Animal Modeling】-Minocycline inhibits the hyperpolarization-activated current of glial neurons in the dorsal horn of rat spinal cord

To study the effect of minocycline on the hyperpolarization-activated current (Ih) of colloidal (SG) neurons in the spinal dorsal horn of rats...

2022-09-26
【Animal Modeling】-Effects of high-fat diet and K/BxN serum on the immune system of ApoE knockout mice

【Animal Modeling】-Effects of high-fat diet and K/BxN serum on the immune system of ApoE knockout mice

To examine the effects of high-fat diet and K/BxN serum on the distribution of immune cells in ApoE knockout (ApoE-/-) mice...

2022-09-26
【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

To study the effects of experimental intervention of normal saline on the microflora and content of short-chain fatty acids in the caecum of broilers, in order to provide a theoretical basis for the study of early microbiota intervention experiments...

2022-09-26
【Animal modeling】-Effect of IGF-1 gene and electrical stimulation therapy on rat model of postpartum stress urinary incontinence

【Animal modeling】-Effect of IGF-1 gene and electrical stimulation therapy on rat model of postpartum stress urinary incontinence

To study the effect of IGF-1 gene therapy on the rat model of postpartum stress urinary incontinence, and to explore the ideal treatment method for the disease...

2022-09-24
【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

To investigate whether CD4+ T cells have the ability to secrete exosomes, and the possibility of CD4+ T cell exosomes participating in inflammation and tumor immune processes...

2022-09-24
【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

To investigate the effect and mechanism of 17β-estradiol on the apoptosis of primary cultured cortical neurons induced by propofol...

2022-09-24
【Animal modeling】-Effect of sesame oil on the expression of insulin sensitivity-related genes in skeletal muscle of insulin-resistant rats

【Animal modeling】-Effect of sesame oil on the expression of insulin sensitivity-related genes in skeletal muscle of insulin-resistant rats

To investigate the effect of a high-fat diet of thulia oil rich in n-3 polyunsaturated fatty acids on insulin sensitivity and the expression of related genes in insulin-resistant rats...

2022-09-24
【Animal modeling】-Exploration of nutritional intervention measures during long-distance transportation of tree shrew

【Animal modeling】-Exploration of nutritional intervention measures during long-distance transportation of tree shrew

To explore appropriate nutritional intervention methods to reduce the adverse effects of stress response caused by long-distance transportation on experimental tree shrew...

2022-09-24
【Animal Modeling】-Preliminary Study on the Toxicity of Different Extracts of Psoralen to Rats

【Animal Modeling】-Preliminary Study on the Toxicity of Different Extracts of Psoralen to Rats

To study the toxicity of oral administration of different extracts of Psoralen to rats, and provide a safety basis for its clinical application...

2022-09-24