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[Animal experiment]-Use the CRISPR/Cas9 system to efficiently edit the Plasmodium genome biophysics revealed that autophagy genes are involved in the regulation of learning and memory functions

[Animal experiment]-Use the CRISPR/Cas9 system to efficiently edit the Plasmodium genome biophysics revealed that autophagy genes are involved in the regulation of learning and memory functions

Through the method of genetic screening of nematodes, the early work of Zhang Hong\\\\\\\'s research group at the Institute of Biophysics of the Chinese Academy of Sciences found that the epg-6 gene is an important autophagy gene unique to multicellu...

2021-10-13
【Animal Modeling】-How to evaluate the detection ability of esterase-1 in the serum of experimental mice?

【Animal Modeling】-How to evaluate the detection ability of esterase-1 in the serum of experimental mice?

Through the detection and comparison of the esterase 1 item in the serum of experimental mice, promote the National Institute of Animal Quality Testing to strengthen quality control and improve detection capabilities...

2021-10-13
【Animal Modeling】-A new type of advanced liver tumor animal model

【Animal Modeling】-A new type of advanced liver tumor animal model

Establish a new animal model of advanced liver tumor by injecting tumor cells into the portal vein...

2021-10-13
【Animal Modeling】-How to establish a rat model of acute lung injury?

【Animal Modeling】-How to establish a rat model of acute lung injury?

Establish a rat model of acute lung injury by injecting lipopolysaccharide (LPS) into the trachea, and observe the changes of lung injury over time...

2021-10-13
How to establish a systemic model of Parkinson\\

How to establish a systemic model of Parkinson

Applying behavioral and molecular imaging methods to dynamically evaluate the systemic model of cynomolgus Parkinson\\\'s disease, stable and effective PD, for preclinical research of drugs, stem cells and other therapies, thereby providing primate m...

2021-10-13
【Animal Modeling】-What is an animal model of B lymphocyte defect?

【Animal Modeling】-What is an animal model of B lymphocyte defect?

The B lymphocyte deficiency model is usually clinically manifested as immunoglobulin deficiency and normal cell-mediated immunity...

2021-10-13
【Animal Modeling】-How to establish a nude mouse model of colon cancer liver metastasis?

【Animal Modeling】-How to establish a nude mouse model of colon cancer liver metastasis?

To establish a colon cancer liver metastasis model with high metastasis rate? easy to use? The results are reliable, and are used in experimental studies to prevent colon cancer metastasis?...

2021-10-13
【Animal Modeling】-How to isolate and identify Enterobacter cloacae in the lungs of rhesus monkeys?

【Animal Modeling】-How to isolate and identify Enterobacter cloacae in the lungs of rhesus monkeys?

Collect dead inflammatory tissues of red-tailed monkeys for pathogen isolation, culture, identification, drug sensitivity test, pathogen and drug sensitivity confirmation, and guide disease diagnosis, treatment, prevention, and clinical medication...

2021-10-13
How to use a negative pressure suction device to extract rat cerebrospinal fluid? -【Animal Modeling】

How to use a negative pressure suction device to extract rat cerebrospinal fluid? -【Animal Modeling】

How to extract rat cerebrospinal fluid by using a negative pressure aspirator to increase the success rate of rat cerebrospinal fluid collection?...

2021-10-13
【Animal Modeling】-How to establish a mouse model of Campylobacter jejuni infection?

【Animal Modeling】-How to establish a mouse model of Campylobacter jejuni infection?

Campylobacter jejuni mainly causes food-borne gastrointestinal diseases and has an important impact on human health. However, the establishment of related mouse infection models is a challenge in the study of this pathogen...

2021-10-13
[Animal Modeling]-Targeted identification of gastric cancer orthotopic transplantation model with heptamethyl cyanine near-infrared fluorescent dye

[Animal Modeling]-Targeted identification of gastric cancer orthotopic transplantation model with heptamethyl cyanine near-infrared fluorescent dye

To study the application effect of heptamethine cyanine near-infrared fluorescence (NIRF) dye in in vivo imaging of orthotopic transplantation models of gastric cancer...

2021-10-13
How to establish a mouse model of preeclampsia in rats? -【Animal Modeling】

How to establish a mouse model of preeclampsia in rats? -【Animal Modeling】

Pre-eclampsia (pre-eclampsia, PE) is a unique disease during pregnancy and one of the main causes of morbidity and death in pregnant women and perinatal infants...

2021-10-12
【Animal Modeling】-Why should BALB/c mice, SD rats and cynomolgus monkey lymphocyte subsets be established?

【Animal Modeling】-Why should BALB/c mice, SD rats and cynomolgus monkey lymphocyte subsets be established?

Collect the results of the determination of peripheral blood lymphocyte subsets completed by the National Center for Drug Safety Evaluation and Monitoring during 2007-2019 in accordance with the Good Laboratory Practice (GLP) conditions of non-clinic...

2021-10-12
【Animal Modeling】-How does chronic inflammatory pain model rats induce anxiety?

【Animal Modeling】-How does chronic inflammatory pain model rats induce anxiety?

Dynamic observation of Freund\\\'s complete adjuvant (CFA)-induced changes in pain mood in rats with chronic inflammatory pain, and explore the time lag induced by anxiety and depression in rats with chronic inflammatory pain...

2021-10-12
【Animal Modeling】-How to construct Fancm knockout mice?

【Animal Modeling】-How to construct Fancm knockout mice?

To construct Fancm gene knockout mice of the Fancmi anemia pathway and study the effect of Fancm gene deletion on the physiological functions of mice, especially the physiological functions of male reproductive organs?...

2021-10-12
How to establish a pressure-overloaded heart failure mouse model? -【Animal Modeling】

How to establish a pressure-overloaded heart failure mouse model? -【Animal Modeling】

Establish a mouse heart failure model, and use ultrasound images and pathological techniques to comprehensively evaluate the characteristic changes in cardiac function and structure during the onset of the disease...

2021-10-12