【Animal Modeling】-Changes of telemetry EEG activity in the sublimbic region of morphine-dependent rats during drug-seeking extinction

To discuss the effects of telemetry EEG activity in the sublimbic region on drug-seeking behavior in morphine-dependent rats during drug-seeking decline and its mechanism...

2023-04-27

【Animal modeling】-Basic metabolic characteristics and expression differences of related genes in Chinese hamsters with spontaneous type 2 diabetes

To investigate the basic metabolic characteristics such as glucose and lipid metabolism, body composition, circadian exercise and metabolism in Chinese hamsters with spontaneous type 2 diabetes mellitus and the expression of related genes in skeletal...

2023-04-27

【Animal modeling】-Protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing loss in guinea pigs

To observe the relationship between guinea pig cochlear autophagy-related proteins beclin1 and LC3, Na+-K+-2Cl- co-transporter (NKCC1) mRNA, endothelin (ET) expression and cochlear gentamicin (GM) injury and piperphentonamine hydrochloride (PPTA) pro...

2023-04-27

【Animal Modeling】-The effect of rapid modeling of KK mouse diet on related indicators of KK/Upj-Ay/J mice

To study the rapid modeling of KK mouse diet and its effect on related indexes in KK/Upj-Ay/J mice...

2023-04-26

【Animal modeling】-Construction and evaluation of non-thoracic aortic arch stenosis heart failure model in mice

To establish a stable and reliable mouse model of heart failure by non-thoracotomy aortic arch stenosis, and to analyze and observe the pathological process of heart failure in mice...

2023-04-26

【Animal Modeling】Effect of -60Coγ-ray radiation on the spleen of naked mole rats

To observe the changes of spleen immune system and tissue biochemical indexes in naked mole-rats after 60Co γ-ray irradiation, and to preliminarily understand the radiation tolerance characteristics of naked mole-rats spleen...

2023-04-26

【Animal Modeling】-Expression and distribution of protein degradation pathway regulatory molecules in mouse nervous system

To investigate the expression and distribution of regulatory molecules of cellular protein degradation pathway in mouse nervous system...

2023-04-26

【Animal Modeling】-Study on the characteristics of spontaneous hindlimb paralysis in hyperlipidemia susceptible (WSHc) rats

To observe the pathogenesis and pathological characteristics of spontaneous hindlimb paralysis rats in the hyperlipidemia susceptible (WSHc) rat population, and to preliminarily study its pathogenesis and explore its application and scientific resear...

2023-04-25

【Animal Modeling】-Aniline-induced DNA damage in mouse hepatocytes and lymphocytes and its repair effect

To study the genotoxicity of aniline and its repair kinetics...

2023-04-25

[Animal modeling] - Differences in the effects of dietary fat on physiological and biochemical indicators of mice in different feed models

To explore the differences of physiological and biochemical indexes of different oils in mice under different feed models, and to provide experimental basis for the selection and evaluation of feed oils in animal models and the use of oils for human...

2023-04-25

【Animal Modeling】-Effect of hydrogen sulfide on myocardial fibrosis and expression of MAPK1/3 and MMP-8 in diabetic rats

To investigate the effect of gas signal molecule hydrogen sulfide (H2S) on myocardial fibrosis and protein expression of MAPK1/3 and MMP-8 in diabetic rats...

2023-04-21

[Animal modeling]-PKH26 and Hoechst 33258 combined to trace Uncv hairless mice iRhom2 and its mutant protein

To use PKH26 and Hoechst 33258 to track the location of Uncv hairless mouse iRhom2 and its mutant protein in Vero cells....

2023-04-21

【Animal modeling】-The role of phosphokinase Czeta in the anterior cingulate cortex in emotional responses in rats with inflammatory pain induced by Freund

To observe the emotional response of CFA-induced inflammatory pain model rats, and to explore the relationship between the anterior cingulate cortex (ACC) phosphokinase Czeta (PKCzeta) and the emotional response of inflammatory pain rats...

2023-04-21

【Animal modeling】-The scavenging effect of arginine antidiuretic hormone on pulmonary edema in rats with acute lung injury

To investigate the effect of arginine antidiuretic hormone (AVP) on pulmonary edema fluid clearance in patients with acute lung injury...

2023-04-21

【Animal modeling】-Construction and research of eukaryotic expression vector of full-length and mature IL-37b

To construct the eukaryotic expression vector pEGFP N1/IL-37b of full-length and mature IL-37b, and to detect the expression of both in RAW 264.7 cells...

2023-04-21

【Animal modeling】-The role of mitochondria-cytochrome C pathway in the apoptosis of rabbit non-alcoholic fatty liver hepatocytes

To investigate the role of mitochondria-cytochrome C pathway in the apoptosis of rabbit non-alcoholic fatty liver liver cells...

2023-04-21