[Animal modeling] - Preliminary study on the establishment of quail gout model with high protein and high calcium diet combined with restricted drinking water

To investigate the method of establishing quail gout model by simulating clinical high protein and high calcium diet to induce Difak quail gout, so as to provide basis for the study of gout pathogenesis and screening of prevention and treatment drugs...

2022-11-03

[Animal modeling] - Comparison of bronchial asthma models induced by different doses of ovalbumin in BALB/c mice

To investigate the effects of different doses of ovalbumin on serum IgE, IL-4 and IFN in BALB/c mice with bronchial asthma γ The content, the number of eosinophils in bronchoalveolar lavage fluid and the influence of lung histopathology, initially de...

2022-11-03

[Animal modeling] - Expression and significance of thrombomodulin in deep vein thrombosis model of rats

To observe the expression and significance of thrombomodulin (TM) in the natural evolution of deep vein thrombosis (DVT) in rats...

2022-11-03

[Animal modeling] Preparation of type III Bama miniature pig model with high tyrosinemia by Hpd gene modification

Using CRISPR/Cas9 technology to knock out 4-hydroxyphenylpyruvate oxidase in Bama miniature pigs, to prepare the type III Bama miniature pig model of hypertyrosinemia...

2022-11-03

[Animal modeling] - Establishment and treatment of nude mouse model of human xenotransplantation of prostate cancer

To establish a human xenotransplantation model of prostate cancer and evaluate the anti-tumor effect of different treatment schemes...

2022-11-03

[Animal modeling] - Comparison of the application of two mycobacterium tuberculosis culture methods in the infection model experiment of tuberculosis mice

To simultaneously verify the therapeutic effect of rifampicin in the tuberculosis infected mouse model by using two mycobacterium tuberculosis culture methods, and to explore the application value of BACTEC MGIT960 culture system in the tuberculosis ...

2022-11-03

[Animal modeling] - Establishment of levofloxacin resistant mouse model

To detect the effect of low concentration of levofloxacin on the pneumonia model of mice infected with Pseudomonas aeruginosa (PA), and explore the method of levofloxacin resistance...

2022-11-03

[Animal modeling] - Comparison of insulin resistance atherosclerosis models between white haired black eye rabbits and Japanese big ear rabbits

To investigate the phenotypic difference and pathological mechanism of insulin resistance atherosclerosis models in white haired black eyed (WHBE) rabbits and Japanese white eared (JW) rabbits...

2022-11-03

[Animal modeling] - Establish a mouse model with seasonal influenza virus H3N2 mouse adaptation strain

To establish a mouse model with the seasonal influenza virus H3N2 mouse adaptation strain, and to explain the molecular mechanism of the change in the pathogenicity of the adaptation strain...

2022-11-03

[Animal modeling] - Establishment of BALB/c nude mice myeloid leukemia model by tail vein injection of M1 cells

To construct M1 leukemia model with BALB/c nude mice...

2022-11-03

[Animal modeling] - Establishment and evaluation of a mouse model of endogenous infection induced by intestinal dissemination

To establish a mouse model of endogenous infection induced by intestinal dissemination, so as to provide a reliable experimental model for studying the mechanism of intestinal microecology and endogenous infection...

2022-11-03

[Animal modeling] - Establishment and preliminary analysis of hyperlipidemia cynomolgus monkey model

To establish a hyperlipidemic cynomolgus monkey model similar to human disease characteristics, and provide an ideal animal model for the research and development of lipid-lowering drugs (especially biological lipid-lowering drugs)...

2022-11-03

[Animal modeling] - Establishment of allergic asthma model in mice aggravated by respiratory administration of antibiotics

The mechanism of traditional Chinese medicine (TCM) treating diseases by regulating the flora has been gradually discovered, and the asthma model of respiratory tract flora disorder caused by antibiotics has been explored to provide a suitable model ...

2022-11-03

[Animal modeling] - sterile APPswe/PS1 Δ Establishment of E9 Double Transgenic Mouse Model and Preliminary Observation of Plaque Changes

To establish aseptic APPswe/PS1 using the method of cesarean section purification Δ E9 (PAP) double transgenic mouse model and preliminary observation of plaque deposition in animal brain, providing a new animal model for studying the relationship be...

2022-11-03

[Animal modeling] - Using orthogonal test to optimize the establishment of rat's conditioned fear memory model

To optimize the best experimental parameters for establishing the rat model of conditioned fear memory by using orthogonal test, and to find the best experimental conditions...

2022-11-03

[Animal modeling] - Analysis of Mozart K448 sonata high frequency sound wave on the intervention treatment of mouse depression model

To establish the depression model of C57BL/6 mice and preliminarily explore the effect of high frequency sound wave in Mozart K448 sonata on improving the depression symptoms of C57BL/6 mice...

2022-11-03