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【Animal Modeling】-HIV virus transgenic animal model

【Animal Modeling】-HIV virus transgenic animal model

The HW-1 long terminal repeat (LTR) is related to the indicator gene of transgenic mice, that is, the LTTR gene is related to the indicator gene-chloramphenicol acetyltransferase (CAT)...

2022-01-10
【Animal Modeling】-Mice herpes virus transgenic animal model

【Animal Modeling】-Mice herpes virus transgenic animal model

Replication method: Construct a nervous system stellate cell-specific expression vector containing human herpes virus 6BU83 gene, microinject it into fertilized mouse egg cells, and then construct a transgenic mouse strain expressing human herpes vir...

2022-01-10
[Animal Modeling]-Effect of Qingzao Jiufei Decoction and its decomposition agent on lung inflammation-related factors in mice infected with Mycoplasma pneumonia

[Animal Modeling]-Effect of Qingzao Jiufei Decoction and its decomposition agent on lung inflammation-related factors in mice infected with Mycoplasma pneumonia

  TNF-α in mice infected with Mycoplasma pneumoniae (MP)? What are the levels of serum INF-γ and MPN372 in lung tissue? P1? To study the effect of Qingzao Jiufei Decoction and its decomposition agent on the expression of AQP5. The molecular mechanism...

2022-01-10
【Animal Modeling】-Comparison of preparation of rat pneumonia models caused by different infection routes

【Animal Modeling】-Comparison of preparation of rat pneumonia models caused by different infection routes

Explore the establishment of a rat model of Pseudomonas aeruginosa pneumonia, and provide experimental basis for follow-up research...

2022-01-10
【Animal modeling】-The effect of simulated aging rat astrocyte conditioned medium on the proliferation of neural stem cells

【Animal modeling】-The effect of simulated aging rat astrocyte conditioned medium on the proliferation of neural stem cells

To establish a rat astrocyte aging model, simulate the aging of astrocytes in aged rats, and explore the effect of aging astrocyte conditioned medium on the proliferation of neural stem cells...

2022-01-10
【Animal Modeling】-Effect and mechanism of acute liver injury in mice on brown adipose tissue function

【Animal Modeling】-Effect and mechanism of acute liver injury in mice on brown adipose tissue function

To investigate the effects of carbon tetrachloride (CC14)-induced acute liver injury on brown adipose tissue in mice at different time points and related mechanisms...

2022-01-10
【Animal modeling】-The role of up-regulation of p-CaMKⅡ expression in dorsal root ganglion in rats with diabetic neuralgia

【Animal modeling】-The role of up-regulation of p-CaMKⅡ expression in dorsal root ganglion in rats with diabetic neuralgia

To observe the expression of phosphorylated calcineurin II (p-CaMK II) in the dorsal root ganglion (DRG) of diabetic neuropathic pain model rats at different stages...

2022-01-10
【Animal modeling】-Effect of astragaloside IV on inflammatory factors and ultrastructure in cerebral ischemia-reperfusion rats

【Animal modeling】-Effect of astragaloside IV on inflammatory factors and ultrastructure in cerebral ischemia-reperfusion rats

To observe the effect of astragaloside IV on inflammatory factors and ultrastructure in cerebral ischemia-reperfusion rats...

2022-01-10
【Animal Modeling】-Urinary Tract Stone Rat Model

【Animal Modeling】-Urinary Tract Stone Rat Model

Male Wistar rats weighing 180-220 g were randomly divided into several groups and fed with normal diet. Before the end of the experiment, a metabolic cage was used to collect and measure the 24-hour urine output and 24-hour oxalic acid (Ox)...

2022-01-07
【Animal Modeling】-Animal Model of Foot-and-Mouth Disease Virus

【Animal Modeling】-Animal Model of Foot-and-Mouth Disease Virus

The replication method uses 0.01 mol/L PBS (pH 7.4) to dilute the foot-and-mouth disease seed virus ORMF8 to LD50 to 10-3 to 10-7/0.2 ml, and then titrate each titer of virus solution dilution. The guinea pig is injected intracutaneously into the toe...

2022-01-07
[Animal Modeling]-Chronic Renal Failure

[Animal Modeling]-Chronic Renal Failure

Chronic renal failure caused by rat freezing [Surgical procedure] Male rats 200-300 g (proteinuria was not measured before surgery). After anesthesia, cut the left side of the abdomen to expose the left side and expose the kidney myocardium. Peel off...

2022-01-07
【Animal Modeling】-Changes of Monoamine Transmitter Content and Expression of Neural Factors in the Brain of Rats with Anxiety Depression

【Animal Modeling】-Changes of Monoamine Transmitter Content and Expression of Neural Factors in the Brain of Rats with Anxiety Depression

To study the changes in the levels of monoamine transmitters in the hippocampus, amygdala, and prefrontal cortex and the expression trends of neurotrophic factors in the brain of an anxiety-induced depression model rat, and explore its possible patho...

2022-01-07
[Animal Modeling]-Stem cells can repair the damaged circuit of Parkinson\\\\

[Animal Modeling]-Stem cells can repair the damaged circuit of Parkinson

Due to degenerative diseases such as stroke and Parkinson\\\\\\\'s disease, it is difficult to repair after injury. The unlimited adaptability of stem cells provides hope for better nerve repair...

2022-01-07
[Animal modeling]-Correlation between the expression of BDNF and VEGF in hippocampus and forebrain cortex and depression induced by chronic stress in mice

[Animal modeling]-Correlation between the expression of BDNF and VEGF in hippocampus and forebrain cortex and depression induced by chronic stress in mice

To explore the correlation between brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) expression in mouse hippocampus and forebrain cortex caused by chronic stress and depression...

2022-01-07
[Animal modeling]-Lateral hydraulic shock brain injury model

[Animal modeling]-Lateral hydraulic shock brain injury model

The lateral hydraulic shock brain injury model quickly injects a certain amount of saline into the cranial cavity, which causes the deformation and displacement of the brain tissue, which leads to TBI...

2022-01-07
What is an animal model of spontaneous liver cirrhosis? -【Animal Modeling】

What is an animal model of spontaneous liver cirrhosis? -【Animal Modeling】

To study the pathological and serum biochemical changes in the liver of Beagle dogs with spontaneous cirrhosis, and to establish background data for experimental animals suitable for GLP...

2022-01-07