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How to prepare an animal model of acute gastric ulcer induced by chemical substances?

How to prepare an animal model of acute gastric ulcer induced by chemical substances?

Reproduction method: adult experimental mice, fasting for 48 hours, oral gavage of ethanol (5 ml/kg body weight) or acetylsalicylic acid (200 mg/kg body weight) or 0.6 mol/L hydrochloric acid (10 ml/kg body weight) 1 After hours, kill the animal by c...

2020-08-07
How to prepare an animal model of chronic atrophic gastritis induced by immune method?

How to prepare an animal model of chronic atrophic gastritis induced by immune method?

Replication method Adult rats, subcutaneously injected 0.3ml/emulsion, made from the same strain of rat gastric mucosa, which contains the same saline tissue homogenate and 1:1 adjuvant, injected subcutaneously, repeated every 3-4 weeks...

2020-08-07
How to prepare an animal model of chronic atrophic gastritis induced by chemical substances?

How to prepare an animal model of chronic atrophic gastritis induced by chemical substances?

Reproductive method Put 0.05% methylnitrosonitrosoguanidine (MNNG) into a drinking bottle for a 5-6 week old rat, and drink 50 ml per mouse per day for 1 month. Or pour 0.01 to 0.02% ammonia water into a water bottle and drink it for 3 to 6 months fo...

2020-08-07
How to prepare an animal model of chronic atrophic gastritis induced by physical factors?

How to prepare an animal model of chronic atrophic gastritis induced by physical factors?

Reproduction method Adult rats take 10 ml/kg body weight once a day in 15% sodium chloride (NaCl) solution at 55°C or simple distilled water at 55°C for 12 to 32 weeks...

2020-08-07
How to prepare an animal model of acute gastritis?

How to prepare an animal model of acute gastritis?

Replication method Adult male rats, fasted for 48 hours, no water, acetylsalicylic acid 100 mg/kg body weight or 10 mmol/L acetic acid or different concentrations of hydrochloric acid (1, 10, 10 mmol/L) or the same type of bile Or 2 mmol. /L Taurine ...

2020-08-07
How to prepare an animal model for cardiopulmonary bypass?

How to prepare an animal model for cardiopulmonary bypass?

Replication method Rats were intraperitoneally injected with sodium pentobarbital at a dose of 30 mg/kg body weight, intubated through the mouth and mechanically ventilated (frequency 60 times)...

2020-08-06
How to prepare an animal model of coronary artery spasm caused by ovariectomy?

How to prepare an animal model of coronary artery spasm caused by ovariectomy?

Reproduction method The female rhesus monkey is surgically removed from the female ovary, the coronary artery (hereinafter referred to as the coronary artery) is contracted using a vasoconstrictor, and the difference with humans is compared by corona...

2020-08-06
How to prepare animal model of right atrial hypertrophy caused by thoracotomy?

How to prepare animal model of right atrial hypertrophy caused by thoracotomy?

Feeding method Under anesthesia, a dog weighing 20-30 kg is injected intravenously with 30 mg/kg sodium pentobarbital, fixed in the right supine position, and intubated through positive pressure ventilation...

2020-08-06
[Animal model]-Rat model of vasculitis obliterans induced by immune method

[Animal model]-Rat model of vasculitis obliterans induced by immune method

Thromboangiitis obliterans is a peripheral vascular disease dominated by autoimmunity, smoking, cold and other external factors and sex hormones are the main cause of the disease. The following describes the method of using the above-mentioned pathog...

2020-08-06
How to prepare an animal model of lauric acid-induced vasculitis obliterans in rats?

How to prepare an animal model of lauric acid-induced vasculitis obliterans in rats?

Reproduction method Anesthetize male Wistar rats weighing 280-320g by intraperitoneal injection of 35 mg/kg body weight of 3% pentobarbital sodium...

2020-08-06
【Animal model】-Portal hypertension model caused by ligation of the common bile duct

【Animal model】-Portal hypertension model caused by ligation of the common bile duct

Reproduction method Anesthetize male Wistar rats weighing 200-250 g by intraperitoneal injection of 30 mg/kg pentobarbital sodium. Cut the abdominal midline on each layer of the abdominal wall and separate the common bile duct...

2020-08-06
【Animal model】-Thioacetamide-induced portal hypertension model in rats

【Animal model】-Thioacetamide-induced portal hypertension model in rats

Replication method Male Wistar rats weighing 150-200 g are injected intraperitoneally with 50 mg/kg of 3% thioacetamide (TAA) once a day for 16 weeks...

2020-08-06
[Animal model]-Rat model of portal hypertension with carbon tetrachloride liver cirrhosis

[Animal model]-Rat model of portal hypertension with carbon tetrachloride liver cirrhosis

Replication method 230-250 g male SD rats were intraperitoneally injected with CCl4 at a dose of 0.15 ml/kg body weight twice a week, and 0.4 g/L phenobarbital solution was used as drinking water for 4 weeks. , Causing a model of chronic liver injury...

2020-08-06
【Animal model】-Canine model of portal hypertension with carbon tetrachloride liver cirrhosis

【Animal model】-Canine model of portal hypertension with carbon tetrachloride liver cirrhosis

Breeding method: Adult experimental dogs are gavaged with CCl4 at a dose of 2 ml/kg body weight twice a week and once a week, and then gavage with 3% sodium pentobarbital after 12 weeks...

2020-08-06
【Animal Model】-Genetic Engineering Atherosclerosis Model

【Animal Model】-Genetic Engineering Atherosclerosis Model

Replication method 6-8 weeks old ApoE gene-deficient mice (C57BL/6J strain), male 18-20g, female half, ω (fat) = 21%, ω (cholesterol) = 0.15%. \"Western diet\" feed (60CO sterilization radiation treatment), feeding condition is level 2, roo...

2020-08-06
【Animal Model】-Destructive hypothalamic arcuate nucleus atherosclerosis model

【Animal Model】-Destructive hypothalamic arcuate nucleus atherosclerosis model

Replication method Neonatal Wistar rats are injected with 10% sodium glutamate (sodium glutamate, MSG) at a dose of 4 g/kg body weight on the 1, 3, 5, 7 and 9 days after birth...

2020-08-06