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How gene therapy treats fatal heart disease

How gene therapy treats fatal heart disease

Danon disease is a very rare life-threatening disease. Its cause is the loss of function of the system responsible for removing and recycling proteins in cells, which will further lead to the function of the heart, skeletal muscle, nervous system, ey...

2021-11-01
Establishment of Potentilla anserine myocardial infarction model and analysis of gene expression profile in infarct marginal zone

Establishment of Potentilla anserine myocardial infarction model and analysis of gene expression profile in infarct marginal zone

Use Potentilla chinensis minipigs and clinically important model indicators to establish a myocardial infarction (myocardial infarction) model, and study the correlation between gene expression and metabolic compensation in the area around myocardial...

2021-11-01
[Animal Modeling]-Inhibitory effect of ursolic acid on rat corneal transplant rejection

[Animal Modeling]-Inhibitory effect of ursolic acid on rat corneal transplant rejection

To explore the therapeutic effect of ursolic acid on rat corneal transplant rejection...

2021-11-01
【Animal Modeling】-The effect of a single intraosseous injection of low-dose simvastatin on angiogenesis after myocardial infarction in rats

【Animal Modeling】-The effect of a single intraosseous injection of low-dose simvastatin on angiogenesis after myocardial infarction in rats

To study the effect of a single local injection of low-dose simvastatin in bone on angiogenesis and cardiac function after myocardial infarction in rats...

2021-11-01
【Animal Modeling】-Adenine-induced Chronic Kidney Disease Rat Model

【Animal Modeling】-Adenine-induced Chronic Kidney Disease Rat Model

Observe the characteristics of mineral metabolism biochemical markers in adenine-induced chronic kidney disease rat model, vascular calcification and renal bone disease?...

2021-11-01
Preclinical safety analysis of rodents and non-human primates

Preclinical safety analysis of rodents and non-human primates

Fibroblast growth factor receptor 1 (FGFR1) belongs to the cell surface FGF receptor family expressed by a certain number of normal tissues, but it is highly amplified and overexpressed in some solid tumors (such as lung cancer and breast cancer)...

2021-11-01
[Animal Experiment]-Use zebrafish to study gene mutations that cause congenital scoliosis

[Animal Experiment]-Use zebrafish to study gene mutations that cause congenital scoliosis

Zebrafish are popular in aquariums around the world and are native to South Asia. However, at the Cincinnati Children’s Institute, the freshwater mutants here play an important role in scientific discoveries...

2021-11-01
How to establish an in vitro apoptosis model of intervertebral disc nucleus pulposus cells? -【Animal Modeling】

How to establish an in vitro apoptosis model of intervertebral disc nucleus pulposus cells? -【Animal Modeling】

Establishment of an in vitro apoptosis model of rat intervertebral disc nucleus pulposus cells...

2021-11-01
Study on the optimization plan of the animal model of Ureaplasma urealyticum infection

Study on the optimization plan of the animal model of Ureaplasma urealyticum infection

Explore the advantages and disadvantages of different modeling methods, and select the most suitable animal model method for Ureaplasma urealyticum infection...

2021-11-01
【Animal Modeling】-How to build a mouse orthotopic transplantation tumor model of human-derived liver cancer cells?

【Animal Modeling】-How to build a mouse orthotopic transplantation tumor model of human-derived liver cancer cells?

Choose 3 strains of human liver cancer cells, inoculate 4 different types of different immunodeficiency mouse liver tissues in situ, establish the orthotopic transplantation model of human liver cancer cells and compare them?...

2021-11-01
【Animal Modeling】-How to establish a mouse model of chronic thrombosis?

【Animal Modeling】-How to establish a mouse model of chronic thrombosis?

The mice were treated by continuous intraperitoneal injection of different concentrations of carrageenan solution, and the disease condition of the mouse model of chronic thrombosis was screened....

2021-11-01
【Animal modeling】-Differential expression of Tibetan miniature pig IGF-1 gene in different growth and development stages and different tissues and organs

【Animal modeling】-Differential expression of Tibetan miniature pig IGF-1 gene in different growth and development stages and different tissues and organs

Determine the expression distribution of IGF-1 gene in Tibetan minipigs of different ages and tissues, and provide basic data for future research...

2021-11-01
【Animal Modeling】-Aural seizure epilepsy model

【Animal Modeling】-Aural seizure epilepsy model

Auditory seizures are a kind of motor seizures, mainly caused by rodents, and are sensitive to auditory seizures when stimulated by bells...

2021-10-29
How to build an experimental rabbit face lifting model? -【Animal Modeling】

How to build an experimental rabbit face lifting model? -【Animal Modeling】

Establish a rabbit face model for the lifting experiment to further evaluate the lifting effect of the plastic tape (plastic tape) on the absorbent soft tissue on the skin, and provide an experimental basis for the clinical application of the plastic...

2021-10-29
【Animal modeling】-animal model of prostate cancer metastasis

【Animal modeling】-animal model of prostate cancer metastasis

Prostate cancer is the most common form of cancer in men, and one in six people suffers from prostate cancer....

2021-10-29
How to establish an animal model of acquired secondary immunodeficiency? -【Animal Modeling】

How to establish an animal model of acquired secondary immunodeficiency? -【Animal Modeling】

  The human body’s immune system is low, and it is easily attacked by internal and external virulence factors, making it a high-risk group with a variety of diseases...

2021-10-29
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