【Animal Modeling】-Cell transplantation in glaucoma mice

A study by the University of Iowa in the United States showed that cell replacement therapy that can reduce intraocular pressure in glaucoma mice and prevent the loss of nerve cells may maintain patients’ vision...

2021-07-14

Immunoprotection against Helicobacter pylori induced by systemic immunization with sodium hydroxide or complete Freund’s adjuvant

Determine if systemic immunity to Helicobacter pylori is available for approved personal use...

2021-07-14

【Animal Modeling】-Solanine inhibits the growth of Du145 transplanted prostate cancer cells in nude mice by inducing cell cycle G1/S block

To study the effect of solanine on the growth of transplanted prostate cancer cells Du145 in nude mice and its molecular mechanism...

2021-07-14

[Animal Modeling] The effect and mechanism of 2,3-butanedione monooxime in improving calcium abnormalities in isolated rat hearts

To explore the effect and mechanism of contracture inhibitor 2,3-butanone oxime (BDM) in improving calcium ion abnormalities in isolated rat hearts...

2021-07-14

【Animal Modeling】-CD45 monoclonal antibody-mediated 188Re-avidin two-step pre-targeting lymphoma experimental study

Establish a CD45 monoclonal antibody-mediated two-step pre-positioning method for 188e-avidin, observe its biological distribution characteristics in cancer-bearing mice, and evaluate its feasibility in the treatment of lymphoma...

2021-07-14

【Animal Modeling】-New polycitric acid filling material induces soft tissue regeneration after skull defect in rats

To evaluate the ability of two new types of biodegradable polycitric acid biomaterials to induce soft tissue regeneration after skull defects in rats...

2021-07-14

[Animal modeling]-Propofol's protection from cerebral ischemia-reperfusion injury may be related to the inhibition of gap junction function

To explore the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junction and its possible mechanism...

2021-07-14

[Animal modeling]-Estrogen reduces the microvascular injury induced by chronic hypoperfusion in the rat brain by up-regulating the expression of VEGF

17-β-estradiol (E2) replacement therapy to study the pathological changes of the brain microvascular system after permanent ligation of bilateral common carotid arteries (BCCAO) in rats and the effect of E2 replacement at different times. The treatme...

2021-07-14

【Animal Modeling】-The effect of IL-27 and its receptor on the proliferation and transformation of lung fibroblasts

To explore the effects of IL-27 and its receptor (WSX-1) on the proliferation, transformation and collagen synthesis of mouse lung fibroblasts induced by TGF-β1...

2021-07-14

Effects of Bile Duct Ligation and Recanalization on Cell Phenotype and NOX4 Protein Expression in Rat Liver

Design and establish a rat liver fibrosis model with biliary tract ligation and recanalization to observe the effect of biliary tract ligation and recanalization on the epithelial mesenchymal phenotype and the expression of oxidative stress-related p...

2021-07-14

【Animal Modeling】-Nrf2 Antioxidant Pathway Protects Rat Acute Liver Injury Induced by CCl4

To study the protective effect of Nrf2 oxidative damage pathway on CCl4-induced acute liver injury in rats...

2021-07-13

[Animal modeling] The protective effect of -γ-secretase inhibitor on the white matter damage of neonatal rats induced by hyperoxia exposure

To explore the effect of γ-secretase inhibitor (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester, DAPT) on the brain white matter damage of neonatal mice exposed to normal pressure and high concentration oxygen Role in...

2021-07-13

【Animal Modeling】-The protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing damage in guinea pigs

Cochlear autophagy-related proteins beclin1 and LC3, Na + -K + -2Cl- complex transporter (NKCC1) mRNA, endoserine (ET) expression, cochlear gentamicin (GM) damage and pipefenone amine hydrochloride (PPTA) Observe relationship protection and damage me...

2021-07-13

Immune protection of Sap2 protein and dendritic cells against systemic Candida albicans infection

Immunize mice with recombinant protein and dendritic cells (DC) to observe its protective effect on systemic Candida albicans...

2021-07-13

Effect of chronic intermittent hypoxia on the expression of glucose transporter 4 in skeletal muscle of rats

To investigate the effects of inflammatory factors caused by chronic intermittent hypoxia-reoxygenation on glucose metabolism and skeletal muscle glucose transporter 4 (GLUT-4) expression in rats...

2021-07-13

【Animal Modeling】-The changes in the EEG activity of the submarginal zone in morphine-dependent rats during the period of drug-seeking subsidence

To explore the effect and mechanism of the changes in EEG activity in the subliminal cortex on the drug-seeking behavior during the sinking process of morphine-dependent rats...

2021-07-13