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【Animal Modeling】-Canine Intraperitoneal Injection of Fecal Filtrate and Abdominal Infection Model

【Animal Modeling】-Canine Intraperitoneal Injection of Fecal Filtrate and Abdominal Infection Model

Anesthetize healthy adult dogs by intraperitoneal injection of sodium pentobarbital with a body weight of 40 mg/kg...

2021-03-25
【Animal Modeling】-Sepsis Rabbit Model

【Animal Modeling】-Sepsis Rabbit Model

Breeding method After local anesthesia with procaine, a New Zealand adult white rabbit is fixed on the operating table in a supine position...

2021-03-25
[Animal modeling]-Thioacetamide (TAA) induced liver failure model

[Animal modeling]-Thioacetamide (TAA) induced liver failure model

  Replication method Adult rats, intraperitoneal injection of thioacetamide (TAA) 250-350 mg/kg body weight, subcutaneous injection of 600 mg/kg body weight, or oral gavage method of 300-400 mg/kg body weight, each rat for 24 hours Rear...

2021-03-24
[Animal Modeling]-Acetaminophen-induced liver failure model

[Animal Modeling]-Acetaminophen-induced liver failure model

Replication method Adult mice were injected with paracetamol (APAP) at a dose of 900 mg/kg body weight, adult rats were injected with 500 mg/kg body weight of APAP in the same way, or adult experimental dogs were injected with dimethyl to dissolve AP...

2021-03-24
【Animal modeling】-Carbon tetrachloride induced liver failure model

【Animal modeling】-Carbon tetrachloride induced liver failure model

Breeding method Adult male rats are forcibly taken orally with 10 ml/kg body weight of 40% CCl4 oil solution, or adult dogs are intraperitoneally injected with 0.9 ml/kg body weight of 50% CCl4 oil solution. The color is the skin of the animal. Obser...

2021-03-24
【Animal Modeling】-Atherosclerosis animal model and characteristics

【Animal Modeling】-Atherosclerosis animal model and characteristics

As early as 1908, Ignatowski and others recognized that a high-cholesterol diet may be related to the formation of experimental atherosclerosis. In 1913, Anichkov and Chalatov established the first atherosclerotic rabbit model with a high-cholesterol...

2021-03-24
[Animal Modeling]-Model of liver cirrhosis induced by common bile duct ligation

[Animal Modeling]-Model of liver cirrhosis induced by common bile duct ligation

Regeneration method Adult rats were anesthetized by umbilical cord median sternotomy, and the common hepatic bile duct was sutured 1 cm away from the hilum with 7-0 silk thread...

2021-03-24
【Animal Modeling】-animal model of stress duodenal ulcer

【Animal Modeling】-animal model of stress duodenal ulcer

Feeding method Adult rats were fasted with water for 16 hours, anesthetized by intraperitoneal injection of sodium pentobarbital, fixed, and then pressed into the coat with electric clippers. The area was slightly larger than the burned area. Pat the...

2021-03-23
【Animal Modeling】-an animal model of chronic gastric ulcer induced by duodenal reflux surgery

【Animal Modeling】-an animal model of chronic gastric ulcer induced by duodenal reflux surgery

Breeding methods Adult rats anesthetized with sodium pentobarbital were fasted for 24 hours without taking water, a midline incision was made in the supine position, the abdomen was opened, left and right anastomosis, and fasting for 3 days after the...

2021-03-23
【Animal Modeling】-Animal model of chronic gastric ulcer induced by acetic acid burning method

【Animal Modeling】-Animal model of chronic gastric ulcer induced by acetic acid burning method

  Reproduction method Anesthetize adult rats with sodium pentobarbital, cut the abdomen into a supine position, and inject 0.01 to 0.05 ml of 20% to 100% acetic acid into the anterior wall of the gastric antrum with tuberculin...

2021-03-23
【Animal Modeling】-Animal model of chronic atrophic gastritis induced by gastrointestinal anastomosis

【Animal Modeling】-Animal model of chronic atrophic gastritis induced by gastrointestinal anastomosis

Breeding method Adult rats fasted for 18 hours, injected pentobarbital sodium 30 mg/kg body weight intraperitoneally under anesthesia, opened the stomach, exposing the stomach and jejunum, and placed the forearm about 2 cm...

2021-03-23
【Animal Modeling】-Genetic Engineering Atherosclerosis Model

【Animal Modeling】-Genetic Engineering Atherosclerosis Model

Replication method 6-8 weeks old ApoE gene-deficient mice (C57BL/6J strain), half male, weighing 18-20 g, ω (fat) = 21%, ω (cholesterol) = 0.15% Western-style diet \"feed (60CO without Bacteria irradiation treatment)\", the feeding conditio...

2021-03-22
[Animal Modeling]-Damaged hypothalamic arcuate nucleus atherosclerosis model

[Animal Modeling]-Damaged hypothalamic arcuate nucleus atherosclerosis model

Replication method Neonatal Wistar rats were injected with 10% monosodium glutamate (MSG) at a dose of 4 g/kg body weight on the 1, 3, 5, 7 and 9 days after birth...

2021-03-22
【Animal Modeling】-A model of atherosclerosis in rabbits induced by high-fat and high-sugar feed

【Animal Modeling】-A model of atherosclerosis in rabbits induced by high-fat and high-sugar feed

Replication method Male experimental rabbits weighing about 2.0 kg were fed a diet that induces diabetes. The feed contains 10% lard and 37% sucrose, and each animal consumes about 75 grams of feed per day...

2021-03-22
【Animal Modeling】-Vitamin D-induced Atherosclerosis Model in Rats

【Animal Modeling】-Vitamin D-induced Atherosclerosis Model in Rats

Breeding method Male Wistar rats weighing 180-200g were injected intraperitoneally with vitamin D 600,000U/kg body weight once, and fed with a basic diet...

2021-03-22
【Animal Modeling】-animal model of rabbit atherosclerosis induced by high-fat and high-cholesterol diet

【Animal Modeling】-animal model of rabbit atherosclerosis induced by high-fat and high-cholesterol diet

  Breeding method Observe the New Zealand rabbits weighing 2.0 to 2.5 kg and 3 to 4 months old. After 1 week, they are fed a diet containing 1.5% cholesterol 80 g/(kg?D) and freely drink water....

2021-03-22