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Although in clinical practice, there are more presbyopia than congenital cataracts, most animal models of genetically engineered cataracts are congenital cataracts...
2021-03-12After sodium selenate reaches the lens of eye tissue through body fluid circulation, on the one hand, it oxidizes the sulfhydryl group of protein, causing Ca2+-ATPase to be inhibited, causing a large amount of Ca2+-ATPase to accumulate in the lens nu...
2021-03-12This type of cataract model uses a variety of drugs to affect the metabolism of the lens and form cataracts...
2021-03-12It is currently believed that retinal damage caused by strong or continuous light is affected by species, region, diet, light history and genetic background pretreatment...
2021-03-12Oxygen induces retinal neovascularization. Pathological angiogenesis is accompanied by abnormal vascular buds that crawl from the retina to the vitreous...
2021-03-12OD mice are the best model for studying human type 1 diabetes, very similar to humans in genetics and immunology...
2021-03-12The middle-wavelength opsin cone dysfunction (MCD) rat in the retinal cone cells is a spontaneous gene mutation rat discovered by the Department of Aerospace Medicine, the Fourth Military Medical University, and is characterized by dark adaptation to...
2021-03-12Tumor necrosis factor-α (TNF-α) is mainly secreted by activated macrophages, and a small amount of activated T cells, NK cells and mast cells are also secreted...
2021-03-11The occurrence of lymphoma is a multi-factorial and multi-stage process. Various mechanisms such as cell cycle regulation, anti-apoptotic pathways, and tumor suppressor pathway abnormalities play an important role in the pathogenesis of lymphoma...
2021-03-11The most commonly used inducer is N-methylnitrosourea (MNU). Its carcinogenic mechanism is related to the formation of O6-methylguanine, resulting in GyA point mutations during DNA replication...
2021-03-11In the synthesis of thyroxine, the iodination reaction of thyroglobulin requires the catalysis of hydrogen peroxide and thyroid peroxidase. Dual oxidases (DUOX) provide hydrogen peroxide in this process. Mutations in the DUOX2 gene can cause hypothyr...
2021-03-11Type 2 diabetes is genetically inherited, and there are many mechanisms involved in the pathogenesis. In order to clarify the role of a single gene in the pathogenesis of type 2 diabetes, a series of type 2 diabetes animal models can be replicated by...
2021-03-11Animal model of diabetes induced by streptozotocin...
2021-03-11Spontaneously diabetic animals, also known as spontaneously hyperglycemic animals, are naturally occurring diabetes in animals, or a diabetes model preserved through genetic breeding. Its performance is very similar to the clinical symptoms of human ...
2021-03-11Intrauterine infection is one of the main causes of premature birth and premature infant diseases...
2021-03-11Perimenopausal period (perimenopausal period) refers to the period from the endocrine, biological and clinical features related to menopause appearing close to menopause to within one year of menopause, that is, the transition period of menopause to ...
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