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【Animal Modeling】-Effects of Oct4 and Cdx2 on the differentiation of inner cell mass and trophectoderm of bovine embryo

【Animal Modeling】-Effects of Oct4 and Cdx2 on the differentiation of inner cell mass and trophectoderm of bovine embryo

Objective To study the effects of Oct4 and Cdx2 knockdown on the expression of genes related to the differentiation of bovine ICM and TE, and to explain the role of Oct4 and Cdx2 in the early development of bovine embryos...

2021-12-31
【Animal Modeling】-The effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in rats with fulminant liver failure

【Animal Modeling】-The effect of alprostadil on eIF2α/ATF4/CHOP pathway and liver function in rats with fulminant liver failure

 Objective To explore the effect of alprostadil (PGE1) on liver function in rats with fulminant hepatic failure (FHF), and to explore its effect on eukaryotic translation initiation factor 2α (eIF2α) / activating transcription factor 4 (ATF4) / C/ EB...

2021-12-31
[Animal Modeling]-Ke Shan Ting regulates skin inflammation and autophagy in mice with psoriasis by inhibiting C5a/C5aR1 pathway

[Animal Modeling]-Ke Shan Ting regulates skin inflammation and autophagy in mice with psoriasis by inhibiting C5a/C5aR1 pathway

This study intends to use imiquimod (IMQ) mouse psoriasis model to explore the regulation effect of Cosentyx on skin inflammation and autophagy in psoriasis mice through the C5a / C5aR1 pathway...

2021-12-31
【Animal Modeling】-The effect of salidroside on Nrf2/Keap1 signaling pathway and wound healing in rats with diabetic foot ulcer

【Animal Modeling】-The effect of salidroside on Nrf2/Keap1 signaling pathway and wound healing in rats with diabetic foot ulcer

Objective To explore the effects of salidroside (Sal) on the nuclear transcription factor E2 related factor 2 / Kelch-like epichlorohydrin related protein 1 (Nrf2 / Keap1) signaling pathway and wound healing in rats with diabetic foot ulcer (DFU)...

2021-12-31
【Animal Modeling】-Cyno-eating monkey muscle atrophy model

【Animal Modeling】-Cyno-eating monkey muscle atrophy model

Establish an animal model of cynomolgus muscle atrophy, and use the method of restricting the movement of the lower limbs to establish a model evaluation method?...

2021-12-30
[Animal Modeling]-Chronic Renal Insufficiency Model

[Animal Modeling]-Chronic Renal Insufficiency Model

Establish a C57BL/6 mouse model of chronic kidney disease, explore the changes in tubule damage indexes and interstitial fibrosis with the dose of cisplatin, and provide animal experimental evidence for the study of the progression from AKI to CKD...

2021-12-30
【Animal modeling】-BALB/c mouse model of total hysterectomy

【Animal modeling】-BALB/c mouse model of total hysterectomy

How to establish a BALB/c mouse total hysterectomy experimental animal model, and investigate and analyze the characteristics and formation mechanism of the model...

2021-12-30
【Animal Modeling】-Animal Model of Depression

【Animal Modeling】-Animal Model of Depression

Neurobiochemical function change model...

2021-12-30
【Animal Modeling】-6-Hydroxydopamine-induced Parkinson\\

【Animal Modeling】-6-Hydroxydopamine-induced Parkinson

Animal: SD rat, female, 2 to 3 months old, weighing 180 to 220 g; drug: 6-hydroxydopamine (6-OHDA), apomorphine, rabbit anti-tyrosine hydroxylase serum, parent Avidin-biotin-peroxidase complex (ABC) kit; equipment: rat brain stereotaxic instrument, 3...

2021-12-30
【Animal Modeling】-Foam Cell Model

【Animal Modeling】-Foam Cell Model

The pathological changes of atherosclerosis include lipid streaks, fibrous plaques, atherosclerotic plaques, compound lesions, etc., while foam cells are the early cytological features of As lesions...

2021-12-30
【Animal Modeling】-Multiple Organ Failure Syndrome (MODS) mouse model

【Animal Modeling】-Multiple Organ Failure Syndrome (MODS) mouse model

The replication method uses 6-8 weeks old KM mice, each mouse is inoculated with Vibrio vulnificus (VV) through different routes (intraperitoneal, intramuscular and subcutaneous injection) 0.2 ml (4.74 X 1000000)...

2021-12-30
【Animal Modeling】-Animal Model of Focal Segmental Glomerulosclerosis

【Animal Modeling】-Animal Model of Focal Segmental Glomerulosclerosis

Overview of the animal model of focal segmental glomerulosclerosis: FSGS causes asymptomatic proteinuria or nephrotic syndrome (NS) with or without renal insufficiency...

2021-12-30
【Animal Modeling】-Animal Model of Diabetic Retinopathy

【Animal Modeling】-Animal Model of Diabetic Retinopathy

Diabetic retinopathy occurs in approximately one-third of diabetic patients. This is the main cause of blindness among adults between the ages of 24 and 70...

2021-12-30
【Animal Modeling】-Subcutaneous transplanted tumor models in different parts of lung cancer

【Animal Modeling】-Subcutaneous transplanted tumor models in different parts of lung cancer

Discuss the differences between subcutaneous xenotransplantation of different parts of lung cancer and provide evidence for lung cancer researchers...

2021-12-30
【Animal Modeling】-A model of memory consolidation disorder caused by electric shock

【Animal Modeling】-A model of memory consolidation disorder caused by electric shock

Modeling material animal: Wistar rat, body weight (216±10) g; equipment: electroconvulsive instrument...

2021-12-30
【Animal Modeling】-Gene knock-in mouse model of hypokalemic hypokalemic periodic paralysis

【Animal Modeling】-Gene knock-in mouse model of hypokalemic hypokalemic periodic paralysis

Using gene knock-in CaV1.1-R528H mice to establish and evaluate hypokalemic periodic paralysis model...

2021-12-30