Quality Control of Chromosome Specimen Preparation for Hamster In Vitro Chromosome Aberration Test

Discuss the influencing factors and quality control of the chromosome preparation process in the in vitro chromosome aberration test, summarize and analyze the successful preparation methods and key points of in vitro chromosome specimens...

2020-11-19

Glycosidase improves the effectiveness and safety of gene delivery by intravitreal injection in mice

Hereditary retinal degeneration is the main cause of blindness. In most forms, genetic mutations affect cells in the outer retina, namely photoreceptors and retinal pigment epithelium (RPE)-making these cells the prime target of emerging gene therapy...

2020-11-19

Mouse test: unique metabolic activation of adipose tissue in obese patients promotes inflammation

Macrophages accumulate in adipose tissue, trigger chronic low-grade inflammation, and promote the development of systemic insulin resistance...

2020-11-19

Intestinal microbial lipopolysaccharide promotes inflammatory senescence in mice

Aging is a degenerative process closely related to inflammation. The typical aging of chronic low-grade inflammation, called \"inflammatory aging\", involves the activation of the inflammatory network and the release of aging-related factor...

2020-11-19

Effects of noise pollution on blood hormones and Hsp-70 levels in rats

To explore the effects of noise pollution on the blood hormone levels and heat shock protein-70 (Hsp-70) expression in rats...

2020-11-19

Exposure of monoclonal antibodies in the cerebrospinal fluid of rats and cynomolgus monkeys after systemic administration

Many studies have focused on the challenge of uptake of small molecules across the blood-brain barrier, while few in-depth studies have evaluated the challenge of uptake of antibodies by the central nervous system (CNS)...

2020-11-19

Mutations in key proteins of autophagy extend healthy lifespan of mice

Autophagy is an evolutionarily conserved protein degradation pathway—eliminating dysfunctional cellular components and recycling their components, which helps to extend the lifespan of model organisms...

2020-11-19

Animal experiments reveal brain mechanisms that drive maternal behavior

In the animal kingdom, the care of female animals is vital to the survival of the young. A study published in the new issue of the American journal Neuron shows that the \"instinct\" of female mice holding pups back into their nests origina...

2020-11-19

Effect of Feilong Palm Blood Extract on Inflammatory Factors in Hyperlipidemia Rats with Myocardial Ischemia

To observe the effect of Toddalia asiatica extract (TAE) on inflammatory factors in rats with hyperlipidemia myocardial ischemia, and to preliminarily explore the mechanism of TAE on cardiovascular protection...

2020-11-19

Analysis of the effect of portal hypertension on serum endotoxin and intestinal mucosa in rats

To study the effect of simple portal hypertension on serum endotoxin and intestinal mucosa in rats?...

2020-11-19

Effect of Tempol on NF-κB signal pathway in rats with cardiac hypertrophy

Explore the effect of 2, 2, 6, 6-tetramethyl-4-piperidinol (temPol) on the NF-κB signaling pathway in rat cardiac hypertrophy?...

2020-11-19

The neuroprotective effect of erythropoietin in a rat model of hypoxic-ischemic encephalopathy

Create a hypoxic ischemic encephalopathy (hyPoxic?ischemic encePhaloPathy, HIE) model in neonatal rats to study the brain protection of recombinant human erythropoietin (EPO) and the changes in the diversity of HIE intestinal flora in neonatal rats. ...

2020-11-19

Injury effect of busulfan on the function of hematopoietic stem cells in mice

To detect the effects of different administration methods on the function of hematopoietic stem cells in mice...

2020-11-18

The effect of vitamin D deficiency on the pathogenesis of spontaneous diabetic rats

To explore the effect of vitamin D (VD) deficiency on the pathogenesis of spontaneous diabetic rats...

2020-11-18

Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

To explore the effect of artificial recombinant botulinum toxin type A heavy chain (BoNT/A heavy chain) on the expression of local growth-related proteins in spinal cord injury in vivo in rats, and provide evidence for elucidating the mechanism of Bo...

2020-11-18

Effects of TRPV4 receptor on renal damage induced by angiotensin II in mice

By using transient receptor potential vanilloid type 4 (TRPV4) gene knockout (TRPV4-/ -) mice, we explored the role of TRPV4 receptor in angiotensin II (angiotensin II, Ang II). Role in induced kidney damage...

2020-11-18