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[Animal modeling] - Shenqi Pill reduces kidney damage in diabetes ZDF rats

[Animal modeling] - Shenqi Pill reduces kidney damage in diabetes ZDF rats

To investigate the intervention effect of Shenqi Pill on renal injury in diabetes ZDF rats and whether its mechanism is to reduce ERS through PERK pathway...

2023-02-08
[Animal modeling] - Effect of matrine on endothelial injury and JAK2/STAT3/SOC1 signal pathway in pregnant hypertensive rats

[Animal modeling] - Effect of matrine on endothelial injury and JAK2/STAT3/SOC1 signal pathway in pregnant hypertensive rats

To investigate the effect of matrine on endothelial injury and tyrosine protein kinase 2/signal transducer and activator of transcription 3/cytokine signal transcription inhibitor 1 (JAK2/STAT3/SOSC1) signal pathway in rats with pregnancy induced hyp...

2023-02-08
[Animal modeling] - Effect of skeletal muscle specific Chrono overexpression on exercise ability and glucose tolerance in mice

[Animal modeling] - Effect of skeletal muscle specific Chrono overexpression on exercise ability and glucose tolerance in mice

The level of skeletal muscle glucose metabolism is an important factor affecting aerobic exercise ability, and the level of skeletal muscle glucose metabolism is regulated by the biological clock...

2023-02-08
[Animal modeling] - Study on the detoxification and protection mechanism of grub peptide extract on lead induced nephrotoxicity in mice

[Animal modeling] - Study on the detoxification and protection mechanism of grub peptide extract on lead induced nephrotoxicity in mice

To explore the mechanism of detoxification and protection of grub peptide extract on mice by establishing a lead acetate induced nephrotoxicity model in order to provide experimental basis for the prevention and treatment of lead induced nephrosis...

2023-02-08
[Animal modeling] - protective effect of paeoniflorin on nerve injury in rats with acute cerebral infarction by activating LKB1/AMPK signal pathway

[Animal modeling] - protective effect of paeoniflorin on nerve injury in rats with acute cerebral infarction by activating LKB1/AMPK signal pathway

To investigate the protective effect of paeoniflorin on nerve injury in rats with acute cerebral infarction by activating hepatic kinase B1 (LKB1)/5 \'- adenosine phosphate activated protein kinase (AMPK) signal pathway...

2023-02-08
[Animal modeling] - Study on the effects of high-sugar and high-fat foods on the growth and metabolic indexes of BALB/c and C57BL/6J mice

[Animal modeling] - Study on the effects of high-sugar and high-fat foods on the growth and metabolic indexes of BALB/c and C57BL/6J mice

To study the growth and metabolism of high-sugar and high-fat foods in inbred BALB/c and C57BL/6J mice, and explore the differential effects of HSHF foods on their growth and metabolism based on different strains and sexes of mice...

2023-02-08
[Animal modeling] - To explore the effect of different concentrations of Matrigel on heterotopic subcutaneous transplanted tumor of Lewis lung cancer in mice

[Animal modeling] - To explore the effect of different concentrations of Matrigel on heterotopic subcutaneous transplanted tumor of Lewis lung cancer in mice

To investigate the effect of different concentrations of Matrigel on heterotopic subcutaneous transplantation of Lewis lung cancer in mice...

2023-02-08
[Animal modeling] - Study on myocardial protection of honokiol on myocardial infarction mice

[Animal modeling] - Study on myocardial protection of honokiol on myocardial infarction mice

To investigate the myocardial protective effect of honokiol on acute myocardial infarction in mice and its possible regulatory mechanism...

2023-02-08
[Animal modeling] - Effect of Sishen Pill on the expression of TLR4 and NOD2 in colon tissue of rats with ulcerative colitis

[Animal modeling] - Effect of Sishen Pill on the expression of TLR4 and NOD2 in colon tissue of rats with ulcerative colitis

To compare the changes of Toll-like receptor 4 (TLR4) and nucleotide-binding oligomeric domain protein 2 (NOD2) in the colon tissue of rats before and after treatment, and to explore the mechanism of Sishen pill in treating ulcerative colitis (UC) fr...

2023-02-08
[Animal modeling] - Resveratrol improvement α- Study on the effect of synaptophysin A53T transgenic mice on motor dysfunction and regulation of peripheral immunity

[Animal modeling] - Resveratrol improvement α- Study on the effect of synaptophysin A53T transgenic mice on motor dysfunction and regulation of peripheral immunity

To study the effect of resveratrol on α- Effects of Synuclein A53T transgenic mice on motor dysfunction and peripheral immunity...

2023-02-08
【Animal Modeling】-Preliminary establishment of genetic testing method for experimental chickens

【Animal Modeling】-Preliminary establishment of genetic testing method for experimental chickens

To establish a genetic detection method of chicken microsatellite DNA for experimental use...

2023-02-07
【Animal Modeling】-Comparison of single staining and counterstaining in the observation of osteoarthritis sections of SIRT1 knockout mice

【Animal Modeling】-Comparison of single staining and counterstaining in the observation of osteoarthritis sections of SIRT1 knockout mice

To establish a related mouse knee osteoarthritis model by knocking out SIRT1 gene, and to observe the differences in the morphology of cartilage tissue sections with different single staining or compound staining techniques...

2023-02-07
【Animal Modeling】-Exploring the effect of stress on appetite in rats from the brain-stomach ghrelin pathway

【Animal Modeling】-Exploring the effect of stress on appetite in rats from the brain-stomach ghrelin pathway

To study the molecular mechanism of stress affecting appetite from the brain ghrelin pathway...

2023-02-07
【Animal Modeling】-Ultraviolet radiation cataract model

【Animal Modeling】-Ultraviolet radiation cataract model

Replication method Healthy adult guinea pigs have the right eye as the irradiated eye and the left eye as the control eye. Use 1% atropine solution to inflate the pupils of both eyes at least twice a week to dilate the pupils by at least 5 mm...

2023-02-07
【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

【Animal Modeling】-Effects of experimental intervention of normal saline on caecal microflora and short-chain fatty acid content in broilers

To study the effects of experimental intervention of normal saline on the microflora and content of short-chain fatty acids in the caecum of broilers, in order to provide a theoretical basis for the study of early microbiota intervention experiments...

2023-02-06
【Animal Modeling】-Hydrogen peroxide-induced changes in isolated rat uterine ligament fibroblasts

【Animal Modeling】-Hydrogen peroxide-induced changes in isolated rat uterine ligament fibroblasts

To investigate the effect and possible mechanism of oxidative stress on the proliferation, apoptosis, collagen synthesis and inflammatory factor expression of uterine ligament fibroblasts...

2023-02-06