Mutations in key proteins of autophagy extend healthy lifespan of mice

Autophagy is an evolutionarily conserved protein degradation pathway—eliminating dysfunctional cellular components and recycling their components, which helps to extend the lifespan of model organisms...

2020-11-19

Animal experiments reveal brain mechanisms that drive maternal behavior

In the animal kingdom, the care of female animals is vital to the survival of the young. A study published in the new issue of the American journal Neuron shows that the \"instinct\" of female mice holding pups back into their nests origina...

2020-11-19

Effect of Feilong Palm Blood Extract on Inflammatory Factors in Hyperlipidemia Rats with Myocardial Ischemia

To observe the effect of Toddalia asiatica extract (TAE) on inflammatory factors in rats with hyperlipidemia myocardial ischemia, and to preliminarily explore the mechanism of TAE on cardiovascular protection...

2020-11-19

Analysis of the effect of portal hypertension on serum endotoxin and intestinal mucosa in rats

To study the effect of simple portal hypertension on serum endotoxin and intestinal mucosa in rats?...

2020-11-19

Effect of Tempol on NF-κB signal pathway in rats with cardiac hypertrophy

Explore the effect of 2, 2, 6, 6-tetramethyl-4-piperidinol (temPol) on the NF-κB signaling pathway in rat cardiac hypertrophy?...

2020-11-19

The neuroprotective effect of erythropoietin in a rat model of hypoxic-ischemic encephalopathy

Create a hypoxic ischemic encephalopathy (hyPoxic?ischemic encePhaloPathy, HIE) model in neonatal rats to study the brain protection of recombinant human erythropoietin (EPO) and the changes in the diversity of HIE intestinal flora in neonatal rats. ...

2020-11-19

Injury effect of busulfan on the function of hematopoietic stem cells in mice

To detect the effects of different administration methods on the function of hematopoietic stem cells in mice...

2020-11-18

The effect of vitamin D deficiency on the pathogenesis of spontaneous diabetic rats

To explore the effect of vitamin D (VD) deficiency on the pathogenesis of spontaneous diabetic rats...

2020-11-18

Effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

To explore the effect of artificial recombinant botulinum toxin type A heavy chain (BoNT/A heavy chain) on the expression of local growth-related proteins in spinal cord injury in vivo in rats, and provide evidence for elucidating the mechanism of Bo...

2020-11-18

Effects of TRPV4 receptor on renal damage induced by angiotensin II in mice

By using transient receptor potential vanilloid type 4 (TRPV4) gene knockout (TRPV4-/ -) mice, we explored the role of TRPV4 receptor in angiotensin II (angiotensin II, Ang II). Role in induced kidney damage...

2020-11-18

Effect of feeding time of high-fat diet on rat model of type 2 diabetic nephropathy

Explore the effects of different high-fat diet feeding time on the blood glucose, insulin resistance index (HOMA-IR) and urinary albumin excretion rate (UAER) of the induced type 2 diabetic nephropathy (DN) rat model?...

2020-11-18

Animal experiments show that e-cigarettes increase the risk of fatty liver

An experiment with mice found that exposure to electronic cigarettes increases the risk of fatty liver in mice. Researchers say this prompts people to use e-cigarettes more cautiously...

2020-11-18

The effect of Jin Siwei on the brain cholinergic system in mice with memory impairment caused by scopolamine

By establishing a memory disorder model of scopolamine, using the traditional Chinese medicine compound Golden Thinking to intervene, observing the effect of Golden Thinking on the behavior and cholinergic system of mice with memory impairment model ...

2020-11-18

Animal experiments show that anticancer drugs can treat social deficits in autism

American scientists have discovered through animal experiments that the anticancer drug romidepsin can restore normal operation of a group of genes related to brain function and alleviate the social behavior defects of autistic rats...

2020-11-18

Repairing effect of platelet-rich plasma on bone defect around implants in rabbits

The use of dental implants has become an important part of modern dental treatment. It is recommended to immediately implant a fresh extraction socket as a means to reduce bone loss and shorten the treatment time of the prosthesis...

2020-11-17

Comparison of Different Methods of Inducing THP-1 Cell Differentiation

Optimize different methods to stimulate the targeted differentiation of THP-1 cells into M1, M2 macrophages and DC cells, laying the foundation for the research of three in vitro cell models of M1, M2 and DC...

2020-11-17