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Oleic acid is a highly toxic fatty acid. When oleic acid is injected into the left renal artery, renal tubular epithelial cells swell and die, interstitial edema, intravascular renal ischemia and severe renal microcirculation. It is impaired and rena...
2022-02-02The experimental animal environment refers to a special artificial place where animals are kept in a limited space controlled by humans and grow, reproduce and experiment according to human wishes. The environment outside the breeding room or animal...
2022-02-02The measurement shall be performed after the completion of the facility, after 48 hours of operation of the air conditioning system or during the normal operation of the facility. During the measurement process, the breeding/breeding area and experim...
2022-02-02Intraperitoneal injection of diazyl am 5 mg/kg and ketamine 50 mg/kg, anesthetize 100-150 g male SD rats, and perform left nephrectomy through midline incision...
2022-02-02Commonly used animals are adult SD or Wistar rats, 120-150g rats, anesthetized with diazepa 5mg/kg and ketamine 50mg/kg, prone position, fixed below the abdomen...
2022-02-02Since the 1960s, the chemical induction method has been started very early, and has become the most mature and commonly used method for preparing IBD models. There are many types of chemical stimulants, such as acetic acid, sodium dextran sulfate, so...
2022-02-02Caerulein is an analog of cholecystokinin (CCK). Cholecystokinin is a polypeptide hormone composed of 33 amino acids. Its main physiological function is to stimulate the contraction of the gallbladder and the relaxation of the Oddi sphincter, promote...
2022-02-02The lateral hydraulic shock brain injury model involves the rapid injection of a certain amount of normal saline into the cranial cavity, causing deformation and displacement of the brain tissue...
2022-02-02Pancreatic cancer is a highly malignant tumor with a poor prognosis. Pancreatic cancer is insidious, difficult to diagnose early, and is prone to liver metastasis, peritoneal spread or local recurrence, and insensitivity to chemotherapy drugs...
2022-02-02The researchers transplanted human liver cells into immunodeficient mice and allowed them to grow in the mice, gradually forming a human-mouse chimeric liver. In this animal model, HBV can survive in human liver cells and be humanized, mouse hepatiti...
2022-02-02Acetaldehyde is an intermediate metabolite of ethanol, which directly damages the liver and converts coenzyme I (NAD) into reduced coenzyme I (NADH) in the liver, thereby reducing the ratio of NAD/NADH. It inhibits the tricarboxylic acid cycle, and t...
2022-02-02By blocking the bile duct or injecting sclerosing agent, the extrahepatic bile duct is artificially blocked, causing the bile duct to expand above the blocked site, cholestasis, and increasing the pressure of the bile duct. I will. Intrahepatic blood...
2022-02-02Methionine-choline deficiency (MCD) diets are commonly used to induce classic NAFLD animal models. MCD diet is rich in carbohydrates (40%) and fat (10%), but lacks methionine and choline, which are involved in the oxidation of fatty acid β in liver c...
2022-02-02The benchmark behavior evaluation of the learning and memory abilities of rodent AD models was mainly tested in the Morris water maze experimental system....
2022-02-02Kawai\\\'s test method is to create a 30 cm x 30 cm x 15 cm plexiglass box with a 6 cm x 6 cm grid engraved on the bottom, and test in a quiet low light environment. After allowing the animal to adapt to the environment for 10 minutes, calculate the ...
2022-02-02Liver cancer model formed by transplanting animal or human liver cancer tissues, cell lines and other malignant tumors into animals...
2022-02-02